Research Project
Grant-in-Aid for Young Scientists (B)
We herein identified peritoneal dissemination-associated genes, such as YAP1, CXCR7 and LOXL1 from an integrated and comprehensive analysis of WES/SNP from 200 cases of GC and gene array database from selected metastatic cell lines.It is now recognized that YAP1 exhibits oncogenic property in GC and the nuclear accumulation correlates with poor survival. We showed that a drug suppressed the growth of GC in vitro and in vivo not by the translocation of YAP1 from cytoplasm into nuclear of cell, but by decreasing the transcription of YAP1 mRNA and protein. Furthermore, low YAP1 mRNA expression was associated with good prognosis in GC. Our findings provided an evidence that could be a novel drug effective in YAP1-dependent GC.Loxl1 and CXCR7 expressions were significantly associated with the poor differentiation, incidence of lymph node metastasis. And the transfectant of each gene in GC cells promoted proliferation, motility and inducing ENT might indicate the fostering dissemination.
All 2016
All Journal Article (1 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 1 results, Open Access: 1 results)
Sci Rep.
Volume: 6 Issue: 1 Pages: 22371-22371
10.1038/srep22371
120006352400
