Elucidation of the role of microRNA-27b for the development of NASH
| Project/Area Number |
15K19341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
IMAJO Kento 横浜市立大学, 附属病院, 助教 (30600192)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 非アルコール性脂肪肝炎 / microRNA-27b / NASH / 腸内細菌 / エンドトキシン |
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| Outline of Final Research Achievements |
In this study, we have clarified that hepatic inflammation induced by hyper responsivity to endotoxin in fatty liver causes lipid excretion and metabolic disturbance by elevating microRNA - 27b (mir-27b), resulting in lipid metabolism disorder and accumulation of free fatty acid (FFA) which causes the development of NASH.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Nonalcoholic Fatty Liver Disease Than Transient Elastography.2016
Author(s)
Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T,Yamanaka T, Wada K, Saito S, Nakajima A
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Journal Title
Gastroenterology
Volume: 150
Issue: 3
Pages: 626-37
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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