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The analysis of GPR120 pathway in colorectal tumor and establishment of EPA chemprevention

Research Project

Project/Area Number 15K19342
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionYokohama City University

Principal Investigator

HIGURASHI Takuma  横浜市立大学, 附属病院, 助教 (90622580)

Co-Investigator(Renkei-kenkyūsha) NAKAJIMA Atsushi  横浜市立大学, 大学院医学研究科, 教授 (30326037)
UMEZAWA Shotaro  横浜市立大学, 医学研究科, 客員研究員 (90737678)
Uchiyama Shiori  横浜市立大学, 医学研究科, 客員研究員 (10714800)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大腸癌 / 化学予防 / GPR120 / EPA / 大腸腫瘍
Outline of Final Research Achievements

Colorectal Cancer (CRC) is increasing. Prevention for CRC, we analyzed the mechanism of GPR120 pathway that is considered the receptor of EPA, one of the omega-3 poly unsaturated fatty acids. EPA suppressed colorectal tumor in wild type mice, not suppressed in GPR120 knock out mice. EPA suppressed colorectal tumor by suppressing MAPK pathway via GPR120. In human, EPA suppressed rectal aberrant crypt foci. Through the research, we showed the probability of CRC chemoprevention using EPA.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] 大腸ポリープ・大腸癌と代謝性疾患・肥満2017

    • Author(s)
      日暮琢磨
    • Journal Title

      臨床消化器内科

      Volume: 32巻7号 Pages: 44-49

    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸上皮におけるパルミチン酸の影響~パルミチン酸は大腸上皮の増殖因子でありACFを増殖させる.2016

    • Author(s)
      内山 詩織、日暮 琢磨、中島 淳
    • Organizer
      JDDW2016
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肥満大腸発癌モデルマウスにおけるEPAによる大腸発癌予防メカニズム‐GPR120を介した経路の検討2016

    • Author(s)
      梅沢 翔太郎、日暮 琢磨、中島 淳
    • Organizer
      JDDW2016
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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