Optimal site of GI-GVHD

• Project/Area Number: 15K19344
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: MINAMINO Hiroaki 大阪市立大学, 大学院医学研究科, 医員 (40597556)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: GVHD / ＧＶＨＤ

Outline of Final Research Achievements

We therefore examined the mRNA expression levels of some inflammatory cytokines (such as tumor necrosis factor α, interferon γ, interleukin 2, etc.) in biopsied specimens from the respective sites. However, we could not confirm a clear association between these cytokine levels and endoscopic mucosal lesions or the diagnostic ratio of GI-GVHD.