Investigation of mechanisms of inflammatory bowel disease caused by interaction of high-fat diet and LRRK2, a susceptibility gene of IBD
| Project/Area Number |
15K19347
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 炎症性腸疾患 / 高脂肪食 / LRRK2 |
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of IBD caused by the interaction of LRRK2, a risk gene for inflammatory bowel disease and high fat diet. In analysis of the expression profile of LRRK2 in the gastrointestinal tract revealed that LRRK2 was mainly localized in the mucosal lamina propria of thecolon and in the auerbach-plexus. Next, intestinal permeability was significantly lowered in the high-fat diet intake group and the LRRK2 knockout mice (LRRK2-KO). Furthermore, comparison of colitis by DSS and TNBS showed that the inflammation was abrogated in the high-fat diet group, on the other hand, DSS colitis was exacerbated in LRRK2-KO. From these results, it was suggested that LRRK2 is involved in intestinal innate immunity.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Maintaining of the Green Fluorescence Emission of 9-Aminoanthracene for Bioimaging Applications.2017
Author(s)
Uchiyama Y, Watanabe R, Kurotaki T, Kuniya S, Kimura S, Sawamura Y, Ohtsuki T, Kikuchi Y, Matsuzawa H, Uchiyama K, Itakura M, Kawakami F, and Maruyama H.
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Journal Title
ACS Omega
Volume: 2
Issue: 7
Pages: 3371-3379
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Selective enhancement of hypoxic cell killing by tempol-regulated suicide gene expression.2015
Author(s)
4.Kagiya G, Ogawa R, Choudhuri R, Cook JA, Hatashita M, Tanaka Y, Koda K, Yamashita K, Kubo M, Kawakami F, Mitchell JB.
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Journal Title
Oncol Rep.
Volume: 34
Issue: 2
Pages: 1065-1073
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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