| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of IBD caused by the interaction of LRRK2, a risk gene for inflammatory bowel disease and high fat diet. In analysis of the expression profile of LRRK2 in the gastrointestinal tract revealed that LRRK2 was mainly localized in the mucosal lamina propria of thecolon and in the auerbach-plexus. Next, intestinal permeability was significantly lowered in the high-fat diet intake group and the LRRK2 knockout mice (LRRK2-KO). Furthermore, comparison of colitis by DSS and TNBS showed that the inflammation was abrogated in the high-fat diet group, on the other hand, DSS colitis was exacerbated in LRRK2-KO. From these results, it was suggested that LRRK2 is involved in intestinal innate immunity.
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