The role of oxidative stress for progression of fatty liver disease

• Project/Area Number: 15K19348
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: Teratani Toshiaki 慶應義塾大学, 医学部(信濃町), 特任助教 (40624408)
• Research Collaborator: SHIMIZU Takahiko 千葉大学, 医学部, 特任准教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 肝臓 / 脂肪肝 / 活性酸素種 / 過酸化水素 / CuZn-SOD

Outline of Final Research Achievements

Nonalcoholic steatohepatitis (NASH) is the more severe form of nonalcoholic fatty liver disease (NAFLD). NASH is pathologically characterized by fat accumulation, inflammation and fibrosis in liver. Metabolic factors such as obesity, insulin resistance, hypertension and dyslipidemia are involved in the progression in NAFLD. Although Oxidative stress is considered as a second hit of NASH pathogenesis, its role in progression of NAFLD was unknown. Hepatic lipid accumulation was reduced in SOD-deficient mice compared to wild type mice. It is suggested that oxidative stress is involved in NAFLD pathogenesis.

Research Products

• [Journal Article] Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice. (2017)
  • Author(s): Nakamoto N, Amiya T, Aoki R, Taniki N, Koda Y, Miyamoto K, Teratani T, Suzuki T, Chiba S, Chu PS, Hayashi A, Yamaguchi A, Shiba S, Miyake R, Katayama T, Suda W, Mikami Y, Kamada N, Ebinuma H, Saito H, Hattori M, Kanai T.
  • Journal Title: Cell Reports Volume: 21 Pages: 1215-1226
  • Peer Reviewed / Open Access
• [Journal Article] Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice (2017)
  • Author(s): Hayashi Atsushi、Mikami Yohei、Miyamoto Kentaro、Kamada Nobuhiko、Sato Toshiro、Mizuno Shinta、Naganuma Makoto、Teratani Toshiaki、Aoki Ryo、Fukuda Shinji、Suda Wataru、Hattori Masahira、Amagai Masayuki、Ohyama Manabu、Kanai Takanori
  • Journal Title: Cell Reports Volume: 20 Issue: 7 Pages: 1513-1524
  • DOI: 10.1016/j.celrep.2017.07.057
  • Peer Reviewed / Open Access
• [Journal Article] Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling (2017)
  • Author(s): Teratani Toshiaki、Tomita Kengo、Suzuki Takahiro、Furuhashi Hirotaka、Irie Rie、Hida Shigeaki、Okada Yoshikiyo、Kurihara Chie、Ebinuma Hirotoshi、Nakamoto Nobuhiro、Saito Hidetsugu、Hibi Toshifumi、Miura Soichiro、Hokari Ryota、Kanai Takanori
  • Journal Title: Journal of Hepatology Volume: 67 Issue: 4 Pages: 780-790
  • DOI: 10.1016/j.jhep.2017.05.020
  • Peer Reviewed / Open Access
• [Journal Article] Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis (2016)
  • Author(s): Amiya T, Nakamoto N, Chu PS, Teratani T, Nakajima H, Fukuchi Y, Taniki N, Yamaguchi A, Shiba S, Miyake R, Katayama T, Ebinuma H, Kanai T.
  • Journal Title: Scientific Reports Volume: ６ Issue: 1 Pages: 1-12
  • DOI: 10.1038/srep35146
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] gut-liver-brain axisによるマウス大腸炎抑制制御メカニズム (2016)
  • Author(s): 寺谷俊昭, 中本伸宏, 千葉明子, 鈴木貴博, 水野慎大, 長沼誠, 金井隆典
  • Organizer: 第５３回日本消化器免疫学会総会
  • Place of Presentation: ホテルニューオータニ大阪
  • Year and Date: 2016-07-14
• [Presentation] Aryl Hydrocarbon Receptorシグナルが、非アルコール性脂肪肝炎-肝臓線維化病態機序に果たす役割に関する検討 (2016)
  • Author(s): 寺谷俊昭, 中本伸宏, 金井隆典
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張, 東京ベイ幕張ホール
  • Year and Date: 2016-05-19