The potential of hepatitis B vaccine: from the B-cell
| Project/Area Number |
15K19352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | National Center for Global Health and Medicine (2016-2017)
Showa University (2015) |
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Principal Investigator |
Hiroyoshi Doi 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (70465102)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | B型肝炎ワクチン / 濾胞性T細胞 / IFNγ / B細胞 / 再接種 / 抗体価 / 免疫応答 / ELISPOT |
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| Outline of Final Research Achievements |
The rational of non- or low- responses to Hepatitis B (HB) vaccine is not well elucidated. We retrospectively analyzed our vaccination records and found acquiring higher titers of anti-HBs by initial vaccination is indispensable for long term maintenance. We also prospectively analyzed the immune responses to HB vaccine using PBMC and sera in first-time vaccinated students. Significant increase of circulating follicular helper T-cell (cTfh) and activated antibody secreting cells (ASC) were observed only in responders. Interestingly, strong association between peripheral IFN-g concentration before vaccination and acquired anti-HBs was observed. Accordingly, tailoring immunological condition, for instance by adding adjuvants or combination vaccine, can be a strategy to rescue non-responders or acquire higher titers of anti-HBs.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] Critical role of B cell lineage in dictating response and non-response to hepatitis B vaccine; A retrospective and prospective study with healthy adults.2017
Author(s)
H. Doi, S. Yoshio, Y. Sakamoto, T. Shimagaki, H. Kawai, N. Nishida, Y. Osawa, H. Yoshida, K. Yoneyama, M. Mizokami, T. Kanto.
Organizer
The Liver Meeting 2017: The 68th Annual Meeting of AASLD.
Related Report
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