| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The rational of non- or low- responses to Hepatitis B (HB) vaccine is not well elucidated. We retrospectively analyzed our vaccination records and found acquiring higher titers of anti-HBs by initial vaccination is indispensable for long term maintenance. We also prospectively analyzed the immune responses to HB vaccine using PBMC and sera in first-time vaccinated students. Significant increase of circulating follicular helper T-cell (cTfh) and activated antibody secreting cells (ASC) were observed only in responders. Interestingly, strong association between peripheral IFN-g concentration before vaccination and acquired anti-HBs was observed. Accordingly, tailoring immunological condition, for instance by adding adjuvants or combination vaccine, can be a strategy to rescue non-responders or acquire higher titers of anti-HBs.
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