New diagnostice methods with OFDI for pulmonary hypertension

• Project/Area Number: 15K19361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Aoki Tatsuo 東北大学, 大学病院, 助教 (00749765)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺高血圧症 / 慢性血栓塞栓性肺高血圧症 / OCT / OFDI

Outline of Final Research Achievements

I examined morphological character of 92 stenotic lesion of pulmonary artery with optical frequency domain imaging (OFDI) in 31 patients with chronic thromboembolic pulmonary hypertension (CTEPH). Mesh network appearance, slit lesion and intramural thrombus were observed in 63, 28 and 65 lesions, respectively. 65 lesions had combined findings.

Research Products

• [Journal Article] Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients With Chronic Thromboembolic Pulmonary Hypertension – Importance of Intrapulmonary Shunt – (2016)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Miyata S, Satoh K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 10 Pages: 2227-2234
  • DOI: 10.1253/circj.CJ-16-0254
  • NAID: 130005418994
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 4 Pages: 636-646
  • DOI: 10.1161/atvbaha.115.306686
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chronic thromboembolic pulmonary hypertension and schizophrenia (2016)
  • Author(s): Suzuki H, Sugimura K, Tatebe S, Aoki T, Shimokawa H
  • Journal Title: Int J Cardiol Volume: 207 Pages: 363-4
  • DOI: 10.1016/j.ijcard.2016.01.010
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Long-term Benificial Effects of Balloon Pulmonary Angiography on Hemodynamics and Prognosis in Patients with Inoperable CTEPH (2017)
  • Author(s): Tatsuo Aoki
  • Organizer: 日本循環器学会、学術集会
  • Place of Presentation: 金沢、日本
  • Year and Date: 2017-03-17
• [Presentation] Safety of Balloon Pulpmonary Angioplasty in Patients with Inoperable CTEPH (2016)
  • Author(s): Tatuso Aoki
  • Organizer: American Heart Association
  • Place of Presentation: ニューオリンズ、アメリカ
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Efficacy and Safety of Balloon Angioplasty in Patients with Inoperable CTEPH (2016)
  • Author(s): Tatuso Aoki
  • Organizer: America Thracic Society
  • Place of Presentation: サンフランシスコ、アメリカ
  • Year and Date: 2016-05-14
  • Int'l Joint Research
• [Presentation] Efficacy and Safety of Balloon Pulmonary Angioplasty in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatsuo Aoki, Koichiro Sugimura, Masanobu Miura, Shunsuke Tatebe, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Haruka Sato, Katsuya Kozu, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: American thoraxic society
  • Place of Presentation: サンフランシスコ、アメリカ
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Effects of Percutaneous Transluminal Pulmonary Angioplasty on Respiratory Functions in Patients with Chronic Thromboembolic Pulmonary Hypertension (2015)
  • Author(s): Tatsuo Aoki, Koichiro Sugimura, Masanobu Miura, Shunsuke Tatebe, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: American heart association
  • Place of Presentation: オーランド、アメリカ
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 末梢型慢性血栓塞栓性肺高血圧症の病変形態 －OFDIによる検討― (2015)
  • Author(s): 神津克也、青木竜男、杉村宏一郎、三浦正暢、建部俊介、 山本沙織、矢尾板信裕、鈴木秀明、佐藤遥、 佐藤公雄、下川宏明
  • Organizer: 日本脈管学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都）
  • Year and Date: 2015-10-29
• [Presentation] 慢性血栓塞栓性肺高血圧症におけるOFDIを用いた病変形態の観察 (2015)
  • Author(s): 青木竜男、杉村宏一郎、三浦正暢、建部俊介、 山本沙織、矢尾板信裕、鈴木秀明、佐藤遥、 神津克也、佐藤公雄、下川宏明
  • Organizer: 日本肺循環学会
  • Place of Presentation: ステーションコンファレンス東京（東京都）
  • Year and Date: 2015-10-03
• [Presentation] Effects of Percutaneous Transluminal Pulmonary Angioplasty on Respiratory Functions in Patients with Chronic Thromboembolic Pulmonary Hypertension (2015)
  • Author(s): Tatsuo Aoki, Koichiro Sugimura, Kotaro Nochioka, Shunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: European respiratory society
  • Place of Presentation: アムステルダム、オランダ
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Effects of PTPA on Respiratory Functions in Patients with Chronic Thromboembolic Pulmonary Hypertension -Possible Negative Influence by Intra-pulmonary Shunt- (2015)
  • Author(s): Tatsuo Aoki, Koichiro Sugimura, Kotaro Nochioka, Shunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: American thoraxic society
  • Place of Presentation: デンバー、アメリカ
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Usefulness of Optical Coherence Tomography Imaging in Management of Chronic Thromboembolic Pulmonary Hypertension (2015)
  • Author(s): Koichiro Sugimura, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Haruka Sato, Kimio Sato, Hiroaki Shimokawa
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Year and Date: 2015-04-24