Translational research for activity of the hippocampus in cardiovascular diseases

• Project/Area Number: 15K19362
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Suzuki Hideaki 東北大学, 医学系研究科, 非常勤講師 (20705462)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心不全 / たこつぼ心筋症 / 海馬 / MRI / うつ病 / 認知症 / ストレス

Outline of Final Research Achievements

Background: Brain and heart diseases adversely affect each other, called as heart-brain axis. Activity of the hippocampus is reduced in patients with depression and dementia.
Result 1: We showed cerebral blood flow in the hippocampus was lower in patients with heart failure, and was associated with depressive symptoms and cognitive dysfunction. Result 2: We showed blood brain-derived neurotrophic factor, which is associated with hippocampal activity, was lower in patients with heart failure, and was correlated with depressive symptoms and cognitive dysfunction. Result 3: We reported takotsubo cardiomyopathy, which is caused by mental and physical stress, was induced by an acute medullary lesion.

Research Products

• [Int'l Joint Research] University College London/Imperial College London(United Kingdom)
• [Int'l Joint Research] University College London/Imperial College(United Kingdom)
• [Journal Article] Delayed autonomic neuropathy in a patient with diethylene glycol poisoning: a case report (2017)
  • Author(s): 1. Kamada H, Suzuki H, Yamamoto S, Nomura R, Kushimoto S
  • Journal Title: Acutu Medicine and Surgery Volume: in press Issue: 3 Pages: 326-328
  • DOI: 10.1002/ams2.267
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced brain-derived neurotrophic factor is associated with cognitive dysfunction in patients with chronic heart failure (2017)
  • Author(s): Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Arai H, Taki Y, Furukawa K, Fukumoto Y, Shimokawa H
  • Journal Title: Geriatrics and Gerontology International Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Focal Reduction in Cardiac ¹²³I-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease (2016)
  • Author(s): 2. Yamamoto S, Suzuki H, Sugimura K, Tatebe S, Aoki T, Miura M, Yaoita N, Sato H, Kozu K, Ota H, Takanami K, Takase K, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Issue: 12 Pages: 2550-2551
  • DOI: 10.1253/circj.CJ-16-0690
  • NAID: 130005285000
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiple sclerosis lesion in the medulla oblongata in a patient with takotsubo cardiomyopathy (2016)
  • Author(s): Kozu K, Suzuki H, Nishiyama S, Yaoita N, Yamamoto S, Tatebe S, Miura M, Aoki T, Hao K, Matsumoto Y, Sugimura K, Aoki M, Shimokawa H
  • Journal Title: International Journal of Cardiology Volume: 222 Pages: 980-981
  • DOI: 10.1016/j.ijcard.2016.08.128
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients With Chronic Thromboembolic Pulmonary Hypertension – Importance of Intrapulmonary Shunt – (2016)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Miyata S, Satoh K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 10 Pages: 2227-2234
  • DOI: 10.1253/circj.CJ-16-0254
  • NAID: 130005418994
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization (2016)
  • Author(s): Takagi H, Ota H, Sugimura K, Otani Katharina, Tominaga J, Aoki T, Tatebe S, Miura M, Yamamoto Y, Sato H, Yaoita N, Suzuki H, Shimokawa H, Takase K
  • Journal Title: European Journal of Radiology Volume: 85 Issue: 9 Pages: 1574-1580
  • DOI: 10.1016/j.ejrad.2016.06.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure (2016)
  • Author(s): 7. Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Furukawa K, Arai H, Fukumoto Y, Taki Y, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Issue: 8 Pages: 1773-1780
  • DOI: 10.1253/circj.CJ-16-0367
  • NAID: 130005166088
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1470-1477
  • DOI: 10.1253/circj.CJ-15-1187
  • NAID: 130005153583
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chronic thromboembolic pulmonary hypertension and schizophrenia (2016)
  • Author(s): Suzuki H, Sugimura K, Tatebe S, Aoki T, Shimokawa H
  • Journal Title: Int J Cardiol Volume: 207 Pages: 363-4
  • DOI: 10.1016/j.ijcard.2016.01.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Patients with Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: in press
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Right-sided infective endocarditis as a potentially fatal complication in patients with long-term refractory severe bradyarrhythmia after cervical spinal cord injury: A case report. (2015)
  • Author(s): Miura N, Suzuki H, Maesawa S, Koakutsu T, Matsumoto Y, Fukuda K, Kagaya Y, Kushimoto S, Shimokawa H.
  • Journal Title: J Arrhythmia. Volume: in press Issue: 4 Pages: 232-234
  • DOI: 10.1016/j.joa.2014.11.002
  • Peer Reviewed / Open Access
• [Journal Article] Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. (2015)
  • Author(s): Suzuki H, Sumiyoshi A, Matsumoto Y, Duffy BA, Yoshikawa T, Lythgoe MF, Yanai K, Taki Y, Kawashima R, Shimokawa H.
  • Journal Title: Neuroimage. Volume: 105 Pages: 84-92
  • DOI: 10.1016/j.neuroimage.2014.10.040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Hippocampus Abnormality is Associated with Depressive Symptoms and Cognitive Impairment in Patients with Chronic Heart Failure (2017)
  • Author(s): Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Furukawa K, Arai H, Fukumoto Y, Taki Y, Shimokawa H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Int'l Joint Research / Invited
• [Presentation] 肺うっ血のコントロールに難渋した急性心不全の一例 (2016)
  • Author(s): 鈴木秀明、三浦正暢、青木竜男、杉村宏一郎、下川宏明
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] Hippocampus Abnormalities Are Associated with Depressive Symptoms and Cognitive Impairment in Patients with Chronic Heart Failure (2016)
  • Author(s): Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miata S, Furukawa K, Arai H, Fukumoto Y, Taki Y, Shimokawa H
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Emerging Role of the Heart-Brain Axis via the Hippocampus in the Pathogenesis of Heart Failure (2016)
  • Author(s): Suzuki H, Matsumoto Y, Sumiyoshi A, Kanata T, Ota H, Yoshikawa T, Sugimura K, Aoki T, Tatebe S, Miura M, Takahashi J, Satoh K, Miata S, Ito K, Furukawa K, Fukumoto Y, Arai H, Yanai K, Kawashima R, Taki Y, Shimokawa H
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Sepsis-induced cardiomyopathyにおける可逆性心筋虚血の関与 (2016)
  • Author(s): 鈴木秀明、工藤大介、久志本成樹
  • Organizer: 第43回日本集中治療医学会学術集会
  • Place of Presentation: 神戸国際展示場（神戸市）
  • Year and Date: 2016-02-13
• [Presentation] 多発性硬化症の脳幹病変によるたこつぼ心筋症の一例 (2015)
  • Author(s): 神津克也、鈴木秀明、西山修平、佐藤遥、矢尾板信裕、山本沙織、羽尾清貴、三浦正暢、建部俊介、青木竜男、 松本泰治、杉村宏一郎、青木正志、下川宏明
  • Organizer: 第161回日本循環器学会東北地方会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2015-12-05
• [Presentation] たこつぼ心筋症患者における 脳の活性化の意義に関する報告 (2015)
  • Author(s): 鈴木 秀明、松本 泰治 、杉村 宏一郎、高橋 潤 、福本 義弘、下川 宏明
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2015-10-16
• [Presentation] 統合失調症に伴う抗リン脂質抗体症候群 で発症した肺塞栓症の一例 (2015)
  • Author(s): 鈴木 秀明、杉村 宏一郎、青木 竜男、建部 俊介、三浦 正暢、山本 沙織、矢尾板 信裕、佐藤 公雄、久志本 成樹、下川 宏明
  • Organizer: 第4回日本肺循環学会 第3回日本肺高血圧学会合同学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都）
  • Year and Date: 2015-10-16
• [Presentation] 「震災に現れた心身相関のインパクト」 震災が心血管疾患に及ぼす影響の意義 (2015)
  • Author(s): 鈴木 秀明、青木 竜男、下川 宏明
  • Organizer: 第22回行動医学会学術総会
  • Place of Presentation: 東北大学医学部艮陵会館（仙台市）
  • Year and Date: 2015-10-02
  • Invited
• [Presentation] Cardiac pacemaker stimulates the brain as well as the heart in humans -A PET functional study- (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano N, Fukuda K, Hiraoka K, Tashiro M, Shimokawa H
  • Organizer: ESC congress 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] 長期人工呼吸管理を要する閉じ込め症候群を呈したネオニコチノイド系農薬による急性中毒の一例 (2015)
  • Author(s): 鎌田裕基、鈴木秀明、野村亮介、下川宏明、久志本成樹
  • Organizer: 第37回日本中毒学会総会・学術集会
  • Place of Presentation: 和歌山県民文化会館 （和歌山県）
  • Year and Date: 2015-06-20
• [Presentation] 髄膜炎にて発症した肺炎球菌による感染性心内膜炎の1例 (2015)
  • Author(s): 伊藤ゆきの、鈴木秀明、大邉寛幸、建部俊介、青木竜男、杉村宏一郎、久志本成樹、下川宏明
  • Organizer: 第205回日本内科学会東北地方会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2015-06-20
• [Presentation] Sepsis-induced encephalopathyによる遷延性意識障害を呈した感染性心内膜炎の1例 (2015)
  • Author(s): 山﨑龍一、鈴木秀明、久志本成樹、下川宏明
  • Organizer: 第205回日本内科学会東北地方会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2015-06-20
• [Presentation] 頭部外傷による抗凝固療法中断後に発症した多発塞栓症の一例 (2015)
  • Author(s): 田中健子、鈴木秀明、浅沼敬一郎、中野誠、杉村宏一郎、坂田泰彦、久志本成樹、下川宏明
  • Organizer: 第205回日本内科学会東北地方会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2015-06-20
• [Presentation] Evidence for Activation of Cerebral Autonomic Center in Reponse to Cardiac Electrical Stimulation in Humans -A New Finding of Cardio-Cerebral Connection- (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano N, Fukuda K, Watanuki S, Hiraoka K, Tashiro M, Shimokawa H
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research