The role of Nicotinamide phosphoribosyltransferase (Nampt) in atrial fibrillation
| Project/Area Number |
15K19366
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
XU DongZhu 筑波大学, 医学医療系, 助教 (20616651)
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| Research Collaborator |
Chen Peng-Sheng Indiana university, Krannert institute of Cardiology, 教授
Chen Zhenhui Indiana university, Krannert institute of Cardiology, 准教授
Murakoshi Nobuyuki 筑波大学, 医学医療系循環器内科, 講師
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 心房細動 / 肥満 / Nampt / カルシウムハンドリング / atrial fibrillation / obesity / NADPH / Ca handling / 心臓電気生理 / Nampt/NAD+/Sirtuin系 / カルシウム調節 |
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| Outline of Final Research Achievements |
In electrophysiological study, Nampt+/-showed increased AF inducibility (80.0% in Nampt+/-+ND, 44.0% in Nampt+/++ND, p<0.05) and duration compared to Nampt+/+, and HFD accelerated longer duration than ND (15.21±5.75 in Nampt+/-+HFD, 8.83±3.33 in Nampt+/-+ND, 6.17±2.66 in Nampt+/++HFD, 3.39±1.07 in Nampt+/++ND, p<0.05). There was no significant difference in fibrotic area between all group. The gene and protein expression levels of Nampt in the atria were decreased by half in the Nampt+/-, and further decreased in Nampt+/-+HFD. The gene expression levels of calcium handling-related molecules Ryr2 and Atp2a2 were decreased in Nampt+/- compared to those of Nampt+/+. These findings suggested that genetic reduction of Nampt increased AF inducibility and duration partially through modulating calcium handling pathway without obvious structural alterations.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Prevalence and clinical determinants of left atrial appendage thrombus in patients with atrial fibrillation before pulmonary vein isolation.2015
Author(s)
Nishikii-Tachibana M, Murakoshi N, Seo Y, Xu DZ, Yamamoto M, Ishizu T, Atsumi A, Machino-Ohtsuka T, Kuroki K, Yamasaki H, Igarashi M, Sekiguchi Y, Aonuma K.
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Journal Title
Am J Cardiol. 2015
Volume: １１６
Pages: 1368-1373
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of supraventricular premature complexes in community-based health checkups: The ibaraki prefectural health study.2015
Author(s)
Murakoshi N, Xu D, Sairenchi T, Igarashi M, Irie F, Tomizawa T, Tada H, Sekiguchi Y, Yamagishi K, Iso H, Yamaguchi I, Ota H, Aonuma K.
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Journal Title
European heart journal.
Volume: ３６
Pages: 170-178
Related Report
Peer Reviewed / Open Access
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