| Project/Area Number |
15K19367
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
NOGAMI Akihiko
MURAKOSHI Nobuyuki
AONUMA Kazutaka
SATO Akira
MACHINO Tomoko
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 腎交感神経アブレーション / 心房細動 / 致死性不整脈 / 治療抵抗性高血圧 / カテーテルアブレーション / 腎交感神経 / 主要心血管イベント / 心室細動 |
|---|
| Outline of Final Research Achievements |
We demonstrated a dose-response relationship between intra-renal adenosine infusion and blood pressure, which can be a new indicator of catheter-based renal denervation. Blood pressure during the renal denervation, however, changed according to fluctuating levels of anesthesia and pain. Those external factors should be controlled for developing a new indicator of renal denervation. We also demonstrated that standard therapies for atrial fibrillation, lethal ventricular arrhythmia, and resistant hypertension were not sufficient for some patients. Those patients with refractory arrhythmias might be good candidates for renal denervation, as well as the resistant hypertension.
|
