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Efficacy and Safety of Branched-Chain Amino Acid For Patients with Cardiac Cachexia

Research Project

Project/Area Number 15K19368
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionThe University of Tokyo

Principal Investigator

TAKATA MUNENORI  東京大学, 医学部附属病院, 助教 (70746841)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsカヘキシア / 慢性心不全 / 分子鎖アミノ酸 / 心臓リハビリテーション / 臨床試験 / 分子鎖アミノ酸製剤 / 運動耐容能改善
Outline of Final Research Achievements

We performed clinical trials (UMIN000019601) "Efficacy and Safety of Add-on Branched-Chain Amino Acid in Cardiac Rehabilitation For Patients with Chronic Heart Failure ". From September 1, 2016, we started the registration of study subjects. As of the end of May 2017, the study drug administration period and follow-up period of the first subject were completed. There had been no severe adverse events to be observed. We are now continuing to recruit new study subjects until the target number of study subjects are achieved.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Phenotypic differences in aortic stenosis according to calcification grade.2016

    • Author(s)
      Takata M, Amiya E, Watanabe M, Shintani Y, Sakuma K, Saito A, Fukayama M, Ono M, Komuro I
    • Journal Title

      International journal of cardiology

      Volume: 216 Pages: 118-120

    • DOI

      10.1016/j.ijcard.2016.04.137

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.2016

    • Author(s)
      Amiya E, Watanabe M, Watanabe S, Takata M, Komuro I.
    • Journal Title

      Springerplus.

      Volume: 5(1) Issue: 1 Pages: 1103-1110

    • DOI

      10.1186/s40064-016-2794-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between orthostatic increase in pulse pressure and ischemic heart disease.2015

    • Author(s)
      Takata M, Amiya E, Watanabe M, Yamada N, Watanabe A, Kawarasaki S, Ozeki A, Nakao T, Hosoya Y, Ando J, Komuro I
    • Journal Title

      Clin Exp Hypertens.

      Volume: 38 Pages: 23-29

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 大規模臨床試験の読み方2015

    • Author(s)
      髙田宗典
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Remarks] 東京大学医学部附属病院 循環器内科 血管内皮・血管機能検査グループの研究内容

    • URL

      https://cardiovasc.m.u-tokyo.ac.jp/study/fmd/about

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学医学部付属病院循環器内科血管内皮・血管機能検査グループ

    • URL

      http://plaza.umin.ac.jp/~utok-card/study/fmd/about

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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