Development of the bionic baroreceptor system for revitalizing BP dysregulation

• Project/Area Number: 15K19382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Hosokawa Kazuya 九州大学, 循環器病未来医療研究センター, 学術研究員 (40746872)
• Research Collaborator: SUNAGAWA Kenji 九州大学, 循環器病未来医療センター, 特任教授 ; SAKU Keita 九州大学, 循環器病未来医療センター, 助教
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 動脈圧反射 / 自律神経制御 / 高血圧 / 低血圧 / 心血管疾患 / 血圧 / 非薬物治療

Outline of Final Research Achievements

We first developed a bionic baroreceptor that is implemented the operating rule that we identified in our previous study, that works same as native baroreceptor. The bionic baroreceptor consists of a computer implemented operating rule, BP telemetry, and a pair of electrodes for a carotid sinus hard-wired to a pulse generator. A swivel connector was used for unrestricting animal. We secondly established the modified sino-aortic denervation (SAD) model that demonstrates labile BP. In modified SAD model, we ligates unilateral common carotid artery instead of preserving the carotid sinus baroreceptor and its nerve. To verify the bionic baroreceptor function, we applied the bionic baroreceptor to freely moving rats with impaired baroreflex function produced by modified SAD (n = 4). The mean BP and BP lability significantly decreased during bionic ON periods compared with OFF periods (mean BP: OFF 123.9±12.1mmHg vs. ON 107.9±8.1mmHg, BP lability: OFF 13.9±1.5 mmHg vs. ON 8.1±2.2 mmHg).

Research Products

• [Journal Article] Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. (2016)
  • Author(s): Sakamoto K, Hosokawa K, Saku K, Sakamoto T, Tobushi T, Oga Y, Kishi T, Ide T, Sunagawa K.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 310 Issue: 2 Pages: H199-H205
  • DOI: 10.1152/ajpheart.00610.2015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Translational Neurocardiology: preclinical models and cardioneural integrative aspects. (2016)
  • Author(s): Ardell JL, Andresen MC, Armour JA, Billman GE, Chen PS, Foreman RD, Herring N, O'Leary DS, Sabbah HN, Schultz HD, Sunagawa K, Zucker IH. Hosokawa K contributed to a part of content
  • Journal Title: J Physiol. Volume: In press Issue: 14 Pages: 3877-3909
  • DOI: 10.1113/jp271869
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Closed-Loop Neuromodulation Technology for Baroreflex Blood Pressure Control. (2016)
  • Author(s): Hosokawa K, Sunagawa K.
  • Journal Title: Proceedings of the IEEE Volume: 104 Pages: 432-443
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 心不全に対する多面的治療戦略～基礎から臨床へ～ 自律神経系の調節制御による心不全治療 (2015)
  • Author(s): 細川和也、坂本和生、砂川賢二
  • Journal Title: 循環器内科 Volume: 78 Pages: 154-159
• [Presentation] Closed Loop Neuromodulation in Cardiovascular Disease (2015)
  • Author(s): Sunagawa K, Saku K, Hosokawa K and Oga Y
  • Organizer: 37th annual international conference of the Engineering in Medicine and Biology Society 2015
  • Place of Presentation: Milano
  • Year and Date: 2015-08-27
  • Int'l Joint Research