PPARgamma-targeting Nanomedicine for the Treatment of Atherosclerotic Plaque Rupture
| Project/Area Number |
15K19384
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
Junchiro Koga 九州大学, 循環器病未来医療研究センター, 学術研究員 (10746142)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子血管学 / 動脈硬化 / ナノメディスン / 分子血管額学 |
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| Outline of Final Research Achievements |
Objective―Inflammatory monocytes/macrophages produce various proteinases and induce rupture of atherosclerotic plaques. We have tested a hypothesis that nanoparticle-mediated delivery of peroxisome proliferator-activated receptor-γ agonist pioglitazone to monocytes/macrophages inhibits plaque ruptures.
Approach and Results―Poly(lactic-co-glycolic-acid) nanoparticles (NPs) were prepared for targeting delivery to monocytes/macrophages. Weekly intravenous administration of pioglitazone-NPs decreased buried fibrous caps, suggesting healed ruptures, in the brachiocephalic arteries of Apoe－/－ mice with a high-fat diet and angiotensin II infusion. Pioglitazone-NPs also inhibited the activity of proteases and decreased expression of inflammatory cytokines in macrophages.
Conclusions―Nanoparticle-mediated delivery of pioglitazone inhibited macrophage activation and plaque ruptures in ApoE-/- mice. These results demonstrate a promising strategy to prevent atherosclerotic plaque ruptures.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.2016
Author(s)
Nakano Y, Matoba T, Tokutome M, Funamoto D, Katsuki S, Ikeda G, Nagaoka K, Ishikita A, Nakano K, Koga J, Sunagawa K, Egashira K
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 29601-29601
DOI
Related Report
Peer Reviewed / Open Access
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