| Project/Area Number |
15K19385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 右室容量負荷 / 成人先天性心疾患 / 心房中隔欠損症 / 心臓MRI / 右室容量負荷の不可逆性 |
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| Outline of Final Research Achievements |
Transcatheter closure of atrial septal defect (ASD) reportedly improves right ventricular (RV) function in patients with ASD. However, it remains uncertain whether transcatheter closure normalizes enlarged RV and its function in adult patients with advanced ASD. The aim of this study is to investigate the long-term impact of transcatheter closure on RV volume and function using cardiac magnetic resonance imaging (CMRI) in adult ASD patients. CMRI was performed at baseline and one-year after transcatheter ASD closure in 40 patients (Median age; 48 year-old: Qp/Qs=2.3). Ten age-matched healthy subjects were enrolled. The parameters of RV and LV were the followings: end-diastolic volume index (EDVI), end-systolic volume index (ESVI) and ejection fraction (EF). One-year after ASD closure, ASD patients showed larger RV volume than healthy subjects (106±3 vs. 77±7 mL in RVEDVI; 58±2 vs. 36±4 mL/m2 in RVESVI, p<0.01). RVEF was reduced (46±8 % vs 51±8 %, P<0.01).
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