The physiological and statistical relationship of a development of heart failure of preserved ejection fraction and an arterial baroreflex dysfunction

• Project/Area Number: 15K19386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Sakamoto Kazuo 九州大学, 医学研究院, 共同研究員 (80722363)
• Research Collaborator: OGA Yasuhiro
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動脈圧受容器反射 / 心不全 / 自律神経不全 / モデル化 / 動脈圧反射

Outline of Final Research Achievements

I clarified the relationship between left atrial pressure fluctuation due to volume intolerance and heart failure in freely moving arterial baroreceptor deficient animal and established a method to stratify the arterial baroreflex function by incorporating a physiological model and computer simulation of baroreflex system. Next, I collected and analyzed the data of blood pressure in humans, and validated the measured blood pressure and optimized the analytical model. Using the analytical model, I found that the elderly's baroreflex function has declined. Furthermore, to improve the simulation accuracy, the analytical model was optimized using heart failure animal models and then the accuracy was improved. The established analytical model of arterial baroreflex function in humans has enabled the quantitative evaluation of the reflex.

Research Products

• [Journal Article] Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure. (2017)
  • Author(s): Arimura T, Saku K, Kakino T, Nishikawa T, Tohyama T, Sakamoto T, Sakamoto K, Kishi T, Ide T, Sunagawa K.
  • Journal Title: Int J Cardiol. Volume: 227 Pages: 704-710
  • DOI: 10.1016/j.ijcard.2016.10.074
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Optimal Titration Is Important to Maximize the Beneficial Effects of Vagal Nerve Stimulation in Chronic Heart Failure. (2016)
  • Author(s): Nishizaki A, Sakamoto K, Saku K, Hosokawa K, Sakamoto T, Oga Y, Akashi T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • Journal Title: J Card Fail Volume: 22 Issue: 8 Pages: 631-638
  • DOI: 10.1016/j.cardfail.2016.04.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. (2016)
  • Author(s): Sakamoto K, Hosokawa K, Saku K, Sakamoto T, Tobushi T, Oga Y, Kishi T, Ide T, Sunagawa K.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 310 Issue: 2 Pages: H199-H205
  • DOI: 10.1152/ajpheart.00610.2015
  • Peer Reviewed / Acknowledgement Compliant