Development of the murine low birth weight model

• Project/Area Number: 15K19388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kumamoto University (2016); National Cardiovascular Center Research Institute (2015)
• Principal Investigator: Arima Yuichiro 熊本大学, 医学部附属病院, 寄附講座教員 (60706414)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 低出生体重 / DOHaD / 動物モデル

Outline of Final Research Achievements

In this study, we tired to generate murine low birth weight models. Using the calorie restriction or early delivery, we successfully established two types of low birth weight models. Serial measurement of body weights showed low birth weight partially normalized in adult. These changes suggested that something compensation mechanisms would work during development.