| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We reported that natriuretic peptide prevented heart failure by inhibiting mineralocorticoid receptor (MR) activity via guanylyl cyclase-A (GC-A). In this study, we found that urinary catecholamine was increased in GC-A KO than wild type mice, indicating the enhanced sympathetic nervous activity. To investigate whether natriuretic peptide inhibits sympathetic nervous activity by inhibiting MR or not, we applied MR blocker to cerebral ventricle. However, urinary catecholamine was not suppressed in GC-A KO mice after intracerebral infusion of MR blocker. We conclude that the enhanced activity of sympathetic nervous system in GC-A KO mice may be independent of MR in the brain.
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