| Project/Area Number |
15K19393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Shimokado Aiko 和歌山県立医科大学, 医学部, 博士研究員 (60508000)
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| Research Collaborator |
MATSUO Yoshiki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 治癒血栓 / 動脈硬化 / 虚血性心疾患 / 光干渉断層像 / 冠動脈プラーク / 光干渉断層法 |
|---|
| Outline of Final Research Achievements |
The aims of this study were to assess agreement between optical coherence tomography (OCT) and histology for healed coronary plaques (HCPs) in human coronary arteries ex vivo. Methods: Ex vivo OCT images were co-registered with histology in
114 cross-sections with more than 50% stenosis. Results: An OCT-derived HCP was defined as a plaque with heterogeneous signal-rich layers of different optical signal density. The sensitivity, specificity, positive predictive value, and negative predictive value of OCT-derived HCP to detect histologically-defined HCPs were 81%, 98%, 93%, and 93% respectively. Conclusions: An ex vivo OCT image has a good agreement with histology for the detection of HCPs. OCT may be a useful intracoronary imaging for detecting HCPs in vivo.
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