Involvement of histone deacetylase 6 in the inducing of atrial fibrillation and atrial remodeling

• Project/Area Number: 15K19394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Iwate Medical University
• Principal Investigator: Matsushita Naoko 岩手医科大学, 医学部, 助教 (30740625)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: HDAC6 / 心房細動 / connexin43 / 炎症性サイトカイン / Connexin43

Outline of Final Research Achievements

We examined roles of histone deacetylase 6 (HDAC6) activation in the induction of atrial fibrillation (AF). Atrial electrical burst pacing (S1S1 = 20-30 msec) for 30 sec significantly increased the frequency of sustained AF induction (lasting more than 5 minutes) in HDAC6 active transgenic (TG) (HDAC6 active-TG) mice compared with non-transgenic (NTG) mice. The mRNA expression of interleukin-18 was increased in HDAC6 active-TG mouse atria compared with NTG mouse atria. Moreover, heterogeneous distribution of connexin43 was observed in HDAC6 active-TG mouse atria but not in NTG mouse atria. The increased interleukin-18 gene expression and changes in connexin43 distribution in atria may play important roles in the HDAC6 activation-induced AF.

Research Products

• [Presentation] Chronic HDAC6 activation induces atrial fibrillation in HDAC6 active transgenic mice (2018)
  • Author(s): 松下尚子
  • Organizer: 日本循環器学会基礎研究フォーラム