Long noncoding RNA in cardiac regeneration
Project/Area Number |
15K19396
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | long non coding RNA / 心筋分化 / non coding RNA / 心筋再生 / 長鎖非コードRNA |
Outline of Final Research Achievements |
Long non coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides, but they do not code proteins. LncRNAs constitute a heterogenic class of RNAs that includes intergenic RNAs, antisense transcripts, and enhancer RNAs. In recent, several studies have been reported that lncRNAs required for cardiac development and disease. It is obvious that many lncRNAs are expressed in cardiac development and are necessary for cardiovascular lineage. However, it has not been investigated in detail how lncRNAs are regulated in cardiac development and heart failure.Using embryonic stem cell (ESC) differentiation strategies, lncRNAs which restricted to cardiac cell were analyzed. In this study, to establish a map of lncRNAs expression and potential target gene networks during ESC differentiation. We identified the potential target genes of these lncRNAs through a bioinformatic correlation network that clusters lncRNAs into specific functional pathway.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Progressive Mycotic Celiac Artery Aneurysm Associated With Coagulase-Negative Staphylococcal Prosthetic Valve Endocarditis2018
Author(s)
Tanaka M, Kohno T, Obara H, Nakatsuka S, Nishiyama T, Nishiyama N, Tsuruta H, Murata M, Maekawa Y, Yoshitake A, Sano M, Shimizu H, Fukuda K. Progressive Mycotic Celiac Artery Aneurysm Associated With Coagulase-Negative Staphylococcal Prosthetic Valve Endocarditis.
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Journal Title
Circulation Journal
Volume: 82
Issue: 7
Pages: 1965-1967
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2018-06-25
Related Report
Peer Reviewed
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[Journal Article] Percutaneous Occlusion of Patent Ductus Arteriosus for an Elderly Patient With Refractory Congestive Heart Failure2018
Author(s)
Shoji S, Kanazawa H, Yanagisawa R, Tanaka M, Fukuoka R, Akita K, Kimura M, Arai T, Kawakami T, Hayashida K, Yuasa S, Tsuruta H, Itabashi Y, Murata M, Nishiyama T, Kohno T, Maekawa Y, Fukuda K
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Journal Title
Circ Heart Fail.
Volume: 11
Related Report
Peer Reviewed
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[Journal Article] The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure2017
Author(s)
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 39752-39752
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Predictive factor and clinical consequence of left bundle-branch block after a transcatheter aortic valve implantation2017
Author(s)
Nishiyama T, Tanosaki S, Tanaka M, Yanagisawa R, Yashima F, Kimura T, Arai T, Tsuruta H, Murata M, Aizawa Y, Kohno T, Maekawa Y, Hayashida K, Takatsuki S, Fukuda K.
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Journal Title
Int J Cardiol.
Volume: 227
Pages: 25-29
DOI
Related Report
Peer Reviewed
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[Journal Article] An RyR2 mutation found in a family with a short-coupled variant of torsade de pointes.2017
Author(s)
Kimura M, Fujisawa T, Aizawa Y, Matsuhashi N, Ito S, Nakajima K, Kashimura S, Kunitomi A, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Yuasa S, Takatsuki S, Kosaki K, Fukuda K.
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Journal Title
Int J Cardiol.
Volume: 227
Pages: 367-369
DOI
Related Report
Peer Reviewed
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[Journal Article] Constrictive Pericarditis and Protein-Losing Enteropathy: Is Extremely Severe Hypoalbuminemia Reversible by Pericardiectomy?2016
Author(s)
Moriyama H, Kohno T, Nishiyama T, Hattori O, Maekawa Y, Yoshida K, Murata M, Okamoto K, Sano M, Shimizu H, Fukuda K
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Journal Title
Circ Heart Fail
Volume: 9
Issue: 12
DOI
Related Report
Peer Reviewed
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[Journal Article] A Novel Mechanism of Atrioventricular Block Following Transcatheter Closure of an Atrial Septal Defect.2016
Author(s)
Yamamoto T, Kanazawa H, Tanosaki S, Goto S, Kimura M, Tsuruta H, Itabashi Y, Murata M, Kunitomi A, Aizawa Y, Nishiyama T, Kohno T, Maekawa Y, Takatsuki S, Sano M, Igawa O, Fukuda K.
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Journal Title
JACC Cardiovasc Interv
Volume: 9(19)
Issue: 19
Pages: 2067-2069
DOI
Related Report
Peer Reviewed
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[Journal Article] Assessment of atrial fibrillation ablation outcomes with clinic ECG, monthly 24-h Holter ECG, and twice-daily telemonitoring ECG2016
Author(s)
Kimura T, Aizawa Y, Kurata N, Nakajima K, Kashimura S, Kunitomi A, Nishiyama T, Katsumata Y, Nishiyama N, Fukumoto K, Tanimoto Y, Fukuda K, Takatsuki S.
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Journal Title
Heart Vessels
Volume: 32
Issue: 3
Pages: 317-325
DOI
Related Report
Peer Reviewed
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[Journal Article] A cost-utility analysis for catheter ablation of atrial fibrillation in combination with warfarin and dabigatran based on the CHADS(2) score in Japan.2016
Author(s)
Kimura T, Igarashi A, Ikeda S, Nakajima K, Kashimura S, Kunitomi A, Katsumata Y, Nishiyama T, Nishiyama N, Fukumoto K, Tanimoto Y, Aizawa Y, Fukuda K, Takatsuki S
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Journal Title
Journal of Cardiology
Volume: 16
Issue: 1
Pages: 89-97
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effective Cibenzoline Treatment in a Patient With Midventricular Obstruction After Transcatheter Aortic Valve Implantation.2016
Author(s)
Isobe S, Ieda M, Kohno T, Nishiyama T, Maekawa Y, Tsuruta H, Murata M, Yashima F, Yanagisawa R, Tanaka M, Inami S, Nasuno T, Haruyama A, Sano M, Hayashida K, Fukuda K.
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Journal Title
Circ Heart Fail
Volume: 9
Issue: 1
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Diagnostic Accuracy of Commercially Available Automated External Defibrillators2015
Author(s)
Nishiyama T, Nishiyama A, Negishi M, Kashimura S, Katsumata Y, Kimura T, Nishiyama N, Tanimoto Y, Aizawa Y, Mitamura H, Fukuda K, Takatsuki S
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Journal Title
Journal of American Heart Association.
Volume: 4
Issue: 12
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Visualization of the left atrial appendage by phased-array intracardiac echocardiography from the pulmonary artery in patients with atrial fibrillation.2015
Author(s)
Nishiyama T, Katsumata Y, Inagawa K, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Aizawa Y, Tanimoto K, Fukuda K, Takatsuki S.
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Journal Title
Europace
Volume: 17
Issue: 4
Pages: 546-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Electrical superior vena cava isolation using photodynamic therapy in a canine model.2015
Author(s)
Kimura T, Takatsuki S, Miyoshi S, Takahashi M, Ogawa E, Nakajima K, Kashimura S, Katsumata Y, Nishiyama T, Nishiyama N, Tanimoto Y, Aizawa Y, Arai T, Fukuda K.
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Journal Title
Europace
Volume: 2
Issue: 2
Pages: 294-300
DOI
Related Report
Peer Reviewed
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