| Project/Area Number |
15K19397
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Keio University |
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Principal Investigator |
Tai Ikue 慶應義塾大学, 医学部(信濃町), 特別研究員(RPD) (90749508)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 網膜血管 / 血管新生 / 血管形成 / テトラスパニン / Tspan18 |
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| Outline of Final Research Achievements |
Tetraspanins (Tspans) are membrane-anchored molecules with 4 transmembrane regions, which promote clustering of other membranous proteins by forming “tetraspanin-enriched microdomain”. Integrins and Immunoglobulin superfamily proteins have been identified as their binding proteins, and thus Tspans are thought to modulate the signal transduction associated with these molecules. However, the function of tetraspanins in vascular development has not been understood well. Here, we found some Tspans are expressed in endothelial cells, especially those in mature (arterial and venous) vessels. Conventional or endothelial-specific knockout of Tspan showed a significant reduction in the number of arterioles and venules and reduced radial vascular growth. In vitro data suggest that Tspan directly interacts with other membrane proteins involved in angiogenesis. Overall, Tspan might regulate the formation of arterioles and venules by clustering other membrane proteins.
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