| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
Intravenous administration of conditioned medium from cultured MSCs (MSC-CM) decreased the atherosclerotic lesions in model mouse. MSC-CM decreased the expression of cell adhesion molecules in endothelial cells (ECs), and decreased the expression of M1 markers and increased the expression of M2 markers in bone marrow derived macrophages. The anti-inflammatory action against ECs were induced by both proteins and exosomes in MSC-CM via inhibition of MAPK and NFkB pathway, and the M1/M2 polarization of macrophages were induced by proteins in MSC-CM via activation of STAT3 pathway and inhibition of MAPK pathway. The results of this study suggest that humoral factors from MSCs are promising for suppression of atherosclerosis by anti-inflammatory actions.
|
