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Pathogenesis and preventive strategies of coronary thrombosis

Research Project

Project/Area Number 15K19404
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Otsuka Fumiyuki  国立研究開発法人国立循環器病研究センター, 病院, 医師 (30745378)

Research Collaborator Ueda Hatsue (Ishibashi Hatsue)  
Yasuda Satoshi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords冠動脈疾患 / 病理 / 血栓症 / 動脈硬化 / 血管内画像診断
Outline of Final Research Achievements

We evaluated histopathology of coronary atherosclerosis and vascular responses to metallic stents in 35 autopsy cases (approximately 1,000 sections) to determine the morphological characteristics of acute and organized thrombosis and calcification. We also performed an ex vivo intracoronary imaging assessment by optical coherence tomography (OCT) in 49 coronary arteries from 22 autopsy cases and compared those images with histopathology. Moreover, we evaluated in vivo OCT images in 25 patients with coronary artery disease who underwent directional coronary atherectomy, compared those images with pathology of the retrieved plaques, and reported the accuracy and the limitations of OCT imaging in an original paper.

Academic Significance and Societal Importance of the Research Achievements

冠動脈血栓症は、急性心筋梗塞や心臓突然死の主要な原因であり、その有効な治療・予防法の確立は極めて大きな社会的意義を有する。冠動脈プラークの形態評価のゴールドスタンダードは病理診断法であり、生体内では主に血管内画像診断法が用いられることから、病理と画像診断との比較検討は実臨床における冠動脈硬化進展過程の評価において極めて重要な意義を有する。本研究を通じて得られた知見は、冠動脈血栓症の病態解明のみならず、画像診断に基づく冠動脈血栓症の高リスク症例同定という点において、非常に有用な情報をもたらすものと考えている。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(15 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 9 results)

  • [Journal Article] In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation.2018

    • Author(s)
      Habara M, Otsuka F, Tsuchikane E, et al.
    • Journal Title

      Int J Cardiol

      Volume: 268 Pages: 1-10

    • DOI

      10.1016/j.ijcard.2018.05.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Embolization of Neoatherosclerosis Following Percutaneous Coronary Intervention: Insights from Near-Infrared Spectroscopy Imaging and Histopathological Analysis2018

    • Author(s)
      Nishihira K, Otsuka F, Kataoka Y, et al.
    • Journal Title

      Circ Cardiovasc Interv.

      Volume: 11

    • DOI

      10.1161/circinterventions.117.006175

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Vivo Tissue Characterization of Human Atherosclerotic Plaques by Optical Coherence Tomography: A Directional Coronary Atherectomy Study with Histopathologic Confirmation2018

    • Author(s)
      Habara M, Otsuka F, Tsuchikane E, et al.
    • Journal Title

      Int J Cardiology

      Volume: in press

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathology of coronary atherosclerosis and thrombosis2016

    • Author(s)
      Otsuka F, Yasuda S, Noguchi T, Ishibashi-Ueda H
    • Journal Title

      Cardiovasc Diagn Ther

      Volume: 6 Pages: 396-408

    • DOI

      10.21037/cdt.2016.06.01

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Update on Vulnerable Coronary Plaques -A Pathological Perspective-.2018

    • Author(s)
      Fumiyuki Otsuka
    • Organizer
      ICoLA 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 病理学からみた石灰化病変とは2018

    • Author(s)
      大塚文之
    • Organizer
      Complex Cardiovascular Therapeutics 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Vulnerable Plaqueを再考する -病理の視点から-2018

    • Author(s)
      大塚文之
    • Organizer
      第66回日本心臓病学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Is there any room for improvement in outcomes after percutaneous coronary intervention? A pathological perspective.2018

    • Author(s)
      大塚文之
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DCAからどんなことを学べるか?2017

    • Author(s)
      大塚文之
    • Organizer
      第7回豊橋ライブデモンストレーション
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] OCTで何が見えるか? DCA切片の病理像との対比を中心に2017

    • Author(s)
      大塚文之
    • Organizer
      第31回日本心臓血管内視鏡学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] A directional coronary atherectomy study with histopathologic confirmation2017

    • Author(s)
      大塚文之
    • Organizer
      Complex Cardiovascular Therapeutics 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] OCT・OFDIで何が見えるのか?病理との対比から2016

    • Author(s)
      大塚文之
    • Organizer
      近畿心血管治療ジョイントライブ2016(KCJL2016)
    • Place of Presentation
      メルパルク京都(京都市下京区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Application and limitation of PCI to calcified lesions: Pathology.2016

    • Author(s)
      大塚文之
    • Organizer
      Complex Cardiovascular Therapeutics 2016
    • Place of Presentation
      神戸国際展示場(神戸市中央区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] What can we learn from DCA? -A pathological perspective-.2016

    • Author(s)
      大塚文之
    • Organizer
      Complex Cardiovascular Therapeutics 2016
    • Place of Presentation
      神戸国際展示場(神戸市中央区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 石灰化病変をどう捉えるか? 病理の視点から再考する2015

    • Author(s)
      大塚 文之
    • Organizer
      第24回日本心血管インターベンション治療学会CVIT2015 学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2015-08-01
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2020-03-30  

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