| Project/Area Number |
15K19406
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | NUT midline carcinoma / Nut midline carcinoma / 次世代シークエンサー / 融合遺伝子 |
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| Outline of Final Research Achievements |
To identify novel therapeutic targets in NUT midline carcinoma (NMC), we examined the gene mutations and comprehensive drug sensitivity screening of NMC, using next generation sequencing and drug panels. We then identified the gene mutation as potential therapeutic target and micro RNA related to cell growth in NMC. We used digital PCR (dPCR) and designed optimal dPCR probes to detect BRD-NUT fusion genes in clinical tumor samples. Consequently, we succeeded in diagnosis of NMC using the dPCR system.
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