| Project/Area Number |
15K19429
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
OHGINO KEIKO 慶應義塾大学, 医学部(信濃町), 助教 (40573324)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | FGF9 / 肺癌 / 分子生物学 / 悪性腫瘍 / 線維芽細胞増殖因子 |
|---|
| Outline of Final Research Achievements |
In recent years, it has been reported that various growth factors including FGF are important in biology of cancer, and we focus on FGF 9 and investigated the role of FGF 9 in lung cancer. FGF9 gene was introduced into lung epithelial cell line and lung cancer cell line not expressing FGF9 to prepare FGF9 overexpressing cells. Overexpression of FGF9 in A549, a cell line of non small cell lung cancer (lung adenocarcinoma), confirmed that it acquired anchorage independent growth ability in FGF9 overexpressing cell line. In the type 2 alveolar epithelial cell line MLE12-FGF9 highly expressing FGF9, subcutaneous transplantation into immunodeficient mice forms small cell carcinoma and it is thought that FGF9 may act as oncogene in lung small cell carcinoma.
|
