Elucidation of the mechanism of cancer progression by cancer-associated lung fibroblasts in non-small cell lung cancer

• Project/Area Number: 15K19430
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Juntendo University
• Principal Investigator: Miniwan Tulafu 順天堂大学, 医学(系)研究科(研究院), 博士研究員 (00739534)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 癌関連肺線維芽細胞 / 非小細胞肺癌 / CAF特異的マーカー / CAFの生理機能活性 / CAF標的創薬 / 癌関連線維芽細胞 / バイオマーカー / コラーゲン / 肺線維芽細胞 / 遊走能 / CAF

Outline of Final Research Achievements

Cancer-associated fibroblasts (CAF) are major component cells in cancer stroma and play a crucial role in accelerating tumor progression interact with cancer cells. Our purpose is to develop new findings, which are led to functional mechanism of cancer-associated fibroblasts (CAF) in lung cancer tissues and development of effective at targeted drugs. CAF-specific markers that regulate the physiological functional activity, it was elucidated that ITGA 11 highly expressed in CAF and is involved in the enhancement of the migration activity. We also found that fibronectin produced from CAF via ITGA 11 expressions. ITGA 11 expressed in CAF is as well expected as a predictive marker of recurrence. Our results provide additional evidence that ITGA11 can modulate cancer associated fibroblast activity and may play a role in lung cancer developments. ITGA11 may be an attractive therapeutic target of cancer stroma to block the lung cancer invasion.

Research Products

• [Presentation] Overexpression of Collagen 11A1 as cancer-associated fibroblasts marker of NSCLC (2017)
  • Author(s): Miniwan Turafu1,2, M.D., Ph.D., Shinsaku Togo1,2, M.D., Ph.D., Yukiko Namba1,2, M.D., Koutarou Kadoya1,2, M.D., Kumi Yoneda Nagahama1,2, M.D., Ph.D., Akira Orimo3, M.D., Ph.D., Kazuhisa Takahashi1,2, M.D., Ph.D
  • Organizer: 第57回日本呼吸器学会総会
  • Place of Presentation: 東京フォーラム
  • Year and Date: 2017-04-21
• [Presentation] Overexpression of Collagen11A1 as cancer -associated fibroblasts marker of NSCLC (2017)
  • Author(s): Miniwan Tulafu
  • Organizer: 第57回日本呼吸器学会