| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
The prevalence of obesity has increased markedly and it is deeply associated with cardiovascular, metabolic, and renal diseases. Some clinical studies have suggested that the salt-sensitivity of blood pressure is enhanced in obese people, and it may be the reason why obese people are prone to develop hypertension, but the mechanism is still unknown.
We hypothesized that abnormality of adipokine specific to obesity may induce the aberrant activation of renal tubular sodium transporters and cause salt-sensitive hypertension. In the comparison of obese and lean salt-sensitive model rats, we demonstrated the same dose of sodium was more likely to develop hypertension and renal impairment in obese rats, and they accompanied abnormality of the renal sodium transporter. Now, we are examining how the abnormality of the adipokines specific to the obesity cause enhanced salt-sensitivity in obese subjects.
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