Impact of a specific gut microbiota change on acute kidney injury mice

• Project/Area Number: 15K19450
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: Nakade Yusuke 金沢大学, 附属病院, 臨床検査技師 (10749360)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 腸内細菌 / 腎臓病 / バイオマーカー / 腸内細菌叢 / 臓器連関 / 腎臓 / 新規バイオマーカー / 治療

Outline of Final Research Achievements

The aim of this study was to reveal the relationship between gut microbiota and kidney disease and to identify new biomarkers for kidney diseases. The contribution of gut microbiota to various disorders has been reported in recent years. However, the association of gut microbiota with kidney disease remains to be investigated. We revealed the alteration of gut bacteria in acute kidney injury mice with 16S rRNA analysis. This result raise the possibility that gut bacteria could be a new candidate of biomarkers for acute kidney injury. A patent has been applied for the biomarker of kidney injury according to our results.

Research Products

• [Journal Article] 腎臓を軸とした生体ネットワークの解明 (2016)
  • Author(s): 中出祐介、和田隆志
  • Journal Title: 臨床病理 Volume: ４ Pages: 387-391
  • NAID: 40020844589
• [Journal Article] Impact of kidney function and urinary protein excretion on intima-media thickness in Japanese patients with type 2 diabetes. (2015)
  • Author(s): Nakade Y, Toyama T, Furuichi K, Kitajima S, Miyajima Y, Fukamachi M, Sagara A, Shinozaki Y, Hara A, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T.
  • Journal Title: Clin Exp Nephrol. Volume: 19 Issue: 5 Pages: 909-917
  • DOI: 10.1007/s10157-015-1088-0
  • Peer Reviewed / Open Access
• [Presentation] 腎臓を軸とした生体ネットワーク機構解明への試み (2016)
  • Author(s): 中出祐介
  • Organizer: 第56回日本臨床化学会
  • Place of Presentation: くまもと県民交流館パレア
  • Year and Date: 2016-12-02
  • Invited
• [Presentation] Vascular damage associated with CKD and laboratory medicine (2016)
  • Author(s): Yusuke Nakade
  • Organizer: The 32nd World Congress of Biomedical Laboratory Science
  • Place of Presentation: Kobe international conference center
  • Year and Date: 2016-08-31
  • Int'l Joint Research
• [Presentation] 腎臓を軸とした生体ネットワークの解明 (2015)
  • Author(s): 中出祐介、和田隆志
  • Organizer: 第62回日本臨床検査医学会学術集会
  • Place of Presentation: 長良川国際会議場・岐阜ホテル
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] eGFR低下は頸動脈IMTの肥厚およびその進行に関連する (2015)
  • Author(s): 中出祐介，遠山直志，古市賢吾，北島信治，宮嶋良康，南部裕子，大江弘康，長原三輝雄，酒井佳夫，和田隆志
  • Organizer: 第62回日本臨床検査医学会学術集会
  • Place of Presentation: 長良川国際会議場・岐阜ホテル
  • Year and Date: 2015-11-19
• [Presentation] Impact of kidney function and urinary protein excretion on pulmonary function (2015)
  • Author(s): Yusuke Nakade, Tadashi Toyama, Kengo Furuichi, Shinji Kitajima, Yasuyuki Shinozaki, Akinori Hara, Miho Shimizu, Yasunori Iwata, Norihiko Sakai, Takashi Wada
  • Organizer: KIDNEY WEEK 2015
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2015-11-04
  • Int'l Joint Research
• [Presentation] Impact of kidney function on intima-media thickness in patients with type 2 diabetes (2015)
  • Author(s): Yusuke Nakade, Tadashi Toyama, Kengo Furuichi, Shinji Kitajima, Akihiro Sagara, Yasuyuki Shinozaki, Akinori Hara, Miho Shimizu, Yasunori Iwata, Norihiko Sakai, Takashi Wada
  • Organizer: KIDNEY WEEK 2015
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2015-11-04
  • Int'l Joint Research
• [Presentation] 慢性腎臓病が頸動脈IMT肥厚に与える影響 (2015)
  • Author(s): 中出祐介，遠山直志，北島信治，相良明宏，原章規，岩田恭宜，清水美保，古市賢吾，和田隆志
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-06-05