Synthetic retinoid Am80, an inhibitor of Kruppel-like factor 5 suppresses the progression of peritoneal fibrosis in a mouse experimental model

Research Project

Project/Area Number	15K19457
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Kidney internal medicine
Research Institution	Nagasaki University
Principal Investigator	MUTA Kumiko 長崎大学, 病院(医学系), 助教 (10728546)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	腹膜透析 / Kruppel-like factor 5 / Am80 / 腹膜線維化 / KLF5
Outline of Final Research Achievements	Kruppel-like transcription factor 5 (KLF5) is a transcription factor regulating biochemical process of cell proliferation, angiogenesis and differentiation. It has been recently reported that Am80, a synthetic retinoic acid receptorα specific agonist, inhibits the expression of KLF5. In the present study, we examined the expression of KLF5 in fibrotic peritoneum induced by chlorhexidine gluconate in mouse, and evaluated that Am80, an inhibitor of KLF5, can reduce peritoneal fibrosis. Our results indicate the involvement of KLF5 in the progression of experimental peritoneal fibrosis and suggest that Am80 may be a potentially useful for the prevention of peritoneal fibrosis through inhibition of KLF5 expression.