The role of chronic inflammation on renal recovery after AKI

• Project/Area Number: 15K19459
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: Hayata Manabu 熊本大学, 医学部附属病院, 助教 (30646120)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性腎障害 / 慢性腎臓病 / 慢性炎症 / AKI / CKD

Outline of Final Research Achievements

It is unclear how the underlying chronic inflammation in lifestyle-related diseases affects on the process of transition from AKI to CKD. In the chronic phase after IRI to the unilateral kidney of B6 mouse, the injured side kidney becomes atrophic. Although similar experiments were conducted using DIO and db/db mice as MetS models, a large amount of subcutaneous fats made it difficult to stabilize the IRI technical procedure enough to evaluate the chronic renal injury. Now, the pathway gene analysis by PCR array is in progress using chronic AKI tissues.

Research Products

• [Journal Article] A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity. (2016)
  • Author(s): Y. Kakizoe, Y. Miyasato, T. Onoue, T. Nakagawa, M. Hayata, K. Uchimura, J. Morinaga, T. Mizumoto, M. Adachi, T. Miyoshi, Y. Sakai, K. Tomita, M. Mukoyama, K. Kitamura
  • Journal Title: Journal of Pharmacological Sciences Volume: 132 Issue: 2 Pages: 145-153
  • DOI: 10.1016/j.jphs.2016.09.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mild systemic thermal therapy ameliorates renal dysfunction in a rodent model of chronic kidney disease. (2016)
  • Author(s): Iwashita Y, Kuwabara T, Hayata M, Kakizoe Y, Izumi Y, Iiyama J, Kitamura K, Mukoyama M.
  • Journal Title: Am J Physiol Renal Physiol. Volume: in press Issue: 11 Pages: 1-1
  • DOI: 10.1152/ajprenal.00519.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model. (2016)
  • Author(s): Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
  • Journal Title: Journal of Pharmacological Sciences Volume: 130 Issue: 2 Pages: 110-116
  • DOI: 10.1016/j.jphs.2016.01.003
  • Peer Reviewed / Open Access
• [Journal Article] The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects. (2015)
  • Author(s): Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Y Sakai, Masashi Mukoyama, Kenichiro Kitamura
  • Journal Title: Nephron Volume: 129 Issue: 3 Pages: 223-232
  • DOI: 10.1159/000375308
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals. (2014)
  • Author(s): Shiraishi N, Kitamura K, Hayata M, Ogata T, Tajiri-Okamura K, Nakayama Y, Kohda Y, Tomita K, Mukoyama M.
  • Journal Title: Am J Kidney Dis. Volume: 65 Issue: 3 Pages: 490-493
  • DOI: 10.1053/j.ajkd.2014.09.028
  • Peer Reviewed
• [Presentation] Myeloid-specific deletion of MRP8 ameliorates glomerulonephritis through affecting macrophage characterization. (2016)
  • Author(s): Kuwabara Takashige, Kiyoshi Mori, Manabu Hayata, Shuro Umemoto, Hideki Yokoi, Masashi Mukoyama.
  • Organizer: American Society of Nephrology Kidney Week 2016
  • Place of Presentation: Chicago, IL
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] Intraglomerular crosstalk between mesangial cells and macrophages in glomerular injury. (2016)
  • Author(s): Shuro Umemoto, Takashige Kuwabara, Manabu Hayata, Daisuke Fujimoto, Tomoko Kanki, Yuichiro Izumi, Yutaka Kakizoe, Masashi Mukoyama.
  • Organizer: American Society of Nephrology Kidney Week 2016
  • Place of Presentation: Chicago, IL
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] Doxycycline ameliorates cisplatin-induced nephrotoxicity in mice through directly acting on proximal tubular cells and promoting cell viability. (2016)
  • Author(s): Terumasa Nakagawa, Yutaka Kakizoe, Naoki Suenaga, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Manabu Hayata, Yuichiro Izumi, Takashige Kuwabara, Masataka Adachi, Hirofumi Jono, Hideyuki Saito, Kenichiro Kitamura, Masashi Mukoyama.
  • Organizer: American Society of Nephrology Kidney Week 2016
  • Place of Presentation: Chicago, IL
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] The role of activated renin-angiotensin system for the MRP8/TLR4 signaling in diabetic nephropathy. (2016)
  • Author(s): Shuro Umemoto, Takashige Kuwabara, Hirotaka Imamaki, Manabu Hayata, Yuichiro Izumi, Yutaka Kakizoe, Kiyoshi Mori, Masashi Mukoyama.
  • Organizer: The 26th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-24
  • Int'l Joint Research
• [Presentation] メタボリックシンドロームモデルラットのポドサイト障害におけるセリンプロテアーゼの役割 (2015)
  • Author(s): 早田 学、水本 輝彦、宮里 賢和、内村 幸平、森永 潤、柿添 豊、酒井 芳紀、向山 政志、北村 健一郎
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-06-07
• [Book] CKDと脂質異常症―脂肪毒性の役割― (2016)
  • Author(s): 早田 学、桒原 孝成、向山 政志
  • Publisher: 最新医学社
• [Book] 腎と透析 (2015)
  • Author(s): 早田学、桒原孝成、向山政志
  • Publisher: 東京医学社
• [Remarks] 熊本大学大学院生命科学研究部 腎臓内科学分野
  • URL: http://www.kumadai-nephrology.com/
• [Remarks] 熊本大学医学部附属病院腎臓内科
  • URL: http://www.kumadai-nephrology.com/