| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Severe proteinuria observed in the High salt group were substantially attenuated by both Camostat and Hydralazine. The reduction levels in BP were comparable, but the anti-proteinuric effect of camostat was much greater than that of Hydralazine. High salt diet induced apoptosis of glomerular epitherial cells through activation of mineralocorticoid receptor. This study suggested that serine protease inhibitor attenuates apoptosis of glomerular epithelial cells and improves urinary protein. Taken together, camostat showed an anti-proteinuric effect by defending podocyte from apoptosis beyond its anti-hypertensive action.
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