Development of novel prediction and treatment with PlGF for caradiovascular diseases and progression of kideny damage in chronic kidney disease

• Project/Area Number: 15K19462
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Nara Medical University
• Principal Investigator: Masaru Matsui 奈良県立医科大学, 医学部, 助教 (70533727)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 心腎連関 / PlGF / 心血管疾患 / 慢性腎臓病 / 末期腎不全 / VEGF / ｓFlt-1 / sFlt-1

Outline of Final Research Achievements

The serum level of PlGF are associated with inflammation and malnutrition due to CKD and its increment are directly correlated with decreasing renal function. PlGF independently predicts cardiovascular events and all-cause mortality in patients with CKD. In addition, the discriminatly abilitiy of PlGF shows almost similar with that of BNP in 2-yr cardiovascular events and its combination use with BNP results in a significant increase in predidctive accurracy of 2-yr cardiovascular events. These data also confirmed in dialysis patients. On the basis of these clinical data, we are analysing and investigating the relation of PlGF with renal hstological changes in human and CKD-model mice.

Research Products

• [Journal Article] Angiogenic Factors and Risks of Technique Failure and Cardiovascular Events in Patients Receiving Peritoneal Dialysis. (2016)
  • Author(s): Matsui M, Samejima K, Takeda Y, Morimoto K, Tagawa M, Onoue K, Okayama S, Kawata H, Kawakami R, Akai Y, Okura H, Saito Y.
  • Journal Title: Cardiorenal Medicine Volume: 6 Issue: 3 Pages: 251-259
  • DOI: 10.1159/000444886
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic Impact of Placental Growth Factor on Mortality and Cardiovascular Events in Dialysis Patients. (2015)
  • Author(s): Matsui M, Samejima K, Takeda Y, Tanabe K, Morimoto K, Okamoto K, Tagawa M, Onoue K, Okayama S, Kawata H, Kawakami R, Akai Y, Saito Y.
  • Journal Title: American Journal of Nephrology Volume: 42 Issue: 2 Pages: 117-125
  • DOI: 10.1159/000439187
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Tsushima H, Matsui M, Tagawa M, Samejima K, Akai Y, Saito Y. (2016)
  • Author(s): Diagnostic utility of stored sFlt-1 for future renal deterioration
  • Organizer: ASN Kidney Week 2016
  • Place of Presentation: America, Chicago
  • Year and Date: 2016-11-15
• [Presentation] Placental Growth Factor (PLGF) Is the Novel Predictor of CKD Progression: The Results from NARA-CKD Study (2015)
  • Author(s): Matsui M, Takeda Y, Morimoto K, Tagawa M, Samejima K, Akai Y, Saito Y
  • Organizer: ASN Kidney Week 2015
  • Place of Presentation: America, Sandiego
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] CKD患者における心血管疾患発症の予測に対する胎盤増殖因子(PlGF)を含むmultimarker modelの有用性 (2015)
  • Author(s): 松井 勝 上村史朗 長谷川礼子 田邊香 岡本恵介 森本勝彦 鮫島謙一 赤井靖宏 斎藤能彦
  • Organizer: 第58回日本腎臓学会
  • Place of Presentation: 横浜
  • Year and Date: 2015-06-05
• [Book] 日本内科学会誌 (2017)
  • Author(s): 松井 勝 斎藤能彦
  • Total Pages: 8
  • Publisher: 日本内科学会
• [Book] 心血管リスクとしてのCKDの重要性を考える (2016)
  • Author(s): 松井 勝
  • Total Pages: 123
  • Publisher: メジカルビュー社