| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The serum level of PlGF are associated with inflammation and malnutrition due to CKD and its increment are directly correlated with decreasing renal function. PlGF independently predicts cardiovascular events and all-cause mortality in patients with CKD. In addition, the discriminatly abilitiy of PlGF shows almost similar with that of BNP in 2-yr cardiovascular events and its combination use with BNP results in a significant increase in predidctive accurracy of 2-yr cardiovascular events. These data also confirmed in dialysis patients. On the basis of these clinical data, we are analysing and investigating the relation of PlGF with renal hstological changes in human and CKD-model mice.
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