The role of glycosylation of renal mineralocorticoid receptor in hypertension and renal dysfunction.
Project/Area Number |
15K19464
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Keio University |
Principal Investigator |
TAKEDA Ayano 慶應義塾大学, 保健管理センター(日吉), 講師 (90468497)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ミネラルコルチコイド受容体(MR) / 糖鎖修飾 / OGT(O-GluNAc転移酵素) / 糖尿病 / OGT〔O-GlcNAc転移酵素) / ミネラルコルチコイド受容体(MR) / OGT(O-GlcNAc転移酵素) |
Outline of Final Research Achievements |
We established podocyte-specific and renal tubule-secific O-GlcNAc transferase (OGT) transgenic mouse models and analyzed their phenotypes to elucidate the effect of glycosylation of mineralocorticoid receptor (MR) in hypertension and renal dysfunction. MR activity examined in kidney tissues was enhanced in renal tubule-specific OGT transgenic mice, which suggested that the glycosylation of MR could be involved in the underlying mechanism of “MR-associated hypertension” in diabetes.
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Report
(3 results)
Research Products
(9 results)
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[Presentation] Essential role of intestinal epithelial mineralocorticoid receptor in the regulation of sodium absorption and blood pressure.2016
Author(s)
Nakamura T, Kurihara I, Kobayashi S, Yokota K, Takeda A, Mitsuishi Y, Morisaki M, Kohata N, Oshima Y, Gunther Schutz, Shibata H, Itoh H.
Organizer
The 26th Scientific Meetings of the International Society of Hypertension.
Place of Presentation
Soul, Korea、Convention and Exhibition Center
Year and Date
2016-09-24
Related Report
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[Presentation] Intestinal epithelial Mineralocorticoid receptor regulates blood pressure through colonic ENaC-mediated sodium absorption2016
Author(s)
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Rie Jo, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
Organizer
41th International Aldosterone Conference
Place of Presentation
ボストン、アメリカ
Year and Date
2016-03-30
Related Report
Int'l Joint Research
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[Presentation] Aldosterone Secretion and MR Sensitivity in High Fat Diet Mice under Equally-adjusted Salt Intake2016
Author(s)
Mitsuha Morisaki, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Rie Jo, Yuko Mitsuishi, Toshifumi Nakamura, Nao Kohata, Yosuke Oshima, Hirotaka Shibata, Hiroshi Itoh
Organizer
41th International Aldosterone Conference
Place of Presentation
ボストン、アメリカ
Year and Date
2016-03-30
Related Report
Int'l Joint Research
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