The physiopathology and clinical significance of anti-MOG positive NMOSD

• Project/Area Number: 15K19472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: SATO DOUGLAS KAZUTOSHI 東北大学, 医学系研究科, 大学院非常勤講師 (80749284)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: antibody / MOG / demyelination / neuromyelitis optica / Antibody / Demyelination / 自己抗体 / 視神経脊髄炎 / ミエリンオリゴデンドロサイト糖蛋白

Outline of Final Research Achievements

Neuromyelitis optica spectrum disorders (NMOSD) is characterised by optic neuritis and myelitis. Most of patients are positive for aquaporin-4 antibodies, but in a proportion of patients, there are seronegative patients with similar characteristics. We reported that some seronegative patients for aquaporin-4 antibodies are positive for anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibodies. Further, anti-MOG positive cases are a group that differs from multiple sclerosis and aquaporin-4 antibody positive NMOSD.

Research Products

• [Int'l Joint Research] Pontifical Cathol Univ of RS/University of Sao Paulo(Brazil)
• [Int'l Joint Research] Oxford University(United Kingdom)
• [Int'l Joint Research] Mahidol University(Thailand)
• [Int'l Joint Research] University of Sao Paulo(Brazil)
• [Int'l Joint Research] INSERM Lyon(France)
• [Int'l Joint Research] National Cancer Center(韓国)
• [Int'l Joint Research] Oxford University(United Kingdom)
• [Int'l Joint Research]
• [Journal Article] MOG-antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy (2017)
  • Author(s): Ogawa R, Nakashima I, Takahashi T, Kaneko K, Akaishi T, Takai Y, Sato DK, Nishiyama S, Misu T, Kuroda H, Aoki M, Fujihara K
  • Journal Title: Neurol Neuroimmunol Neuroinflamm Volume: 16 Issue: 2
  • DOI: 10.1212/nxi.0000000000000322
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies (2017)
  • Author(s): Fujimori J, Takai Y, Nakashima I, Sato DK, Takahashi T, Kaneko K, Nishiyama S, Watanabe M, Tanji H, Kobayashi M, Misu T, Aoki M, Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 印刷中 Issue: 6 Pages: 534-536
  • DOI: 10.1136/jnnp-2016-315094
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Post-vaccination MDEM associated with MOG antibody in a subclinical Chlamydia infected boy. (2016)
  • Author(s): Azumagawa K, Nomura S, Shigeri Y, Jones LS, Sato DK, Nakashima I, Kashiwagi M, Tanabe T, Shimakawa S, Nakajima H, Tamai H.
  • Journal Title: Brain Dev Volume: 38 Issue: 7 Pages: 690-693
  • DOI: 10.1016/j.braindev.2016.02.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lesion length of optic neuritis impacts visual prognosi in neuromyelitis optica (2016)
  • Author(s): Akaishi T, Ichiro Nakashima, Takeshita T, Mugikura S, Sato DK, Takahashi T, Nishiyama S, Kurosawa K, Misu T, Nakazawa T, Aoki M, Fujihara K
  • Journal Title: J Neuroimmunol Volume: 293 Pages: 28-33
  • DOI: 10.1016/j.jneuroim.2016.02.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies (2016)
  • Author(s): Kaneko K, Sato DK, Nakashima I, Nishiyama S, Tanaka S, Marignier R, Hyun JW, Oliveira LM, Reindl M, Seifert-Held T, Sepulveda M, Siritho S, Waters PJ, Kurosawa K, Akaishi T, Kuroda H, Misu T, Prayoonwiwat N, Berger T, Saiz A, Kim HJ, Nomura K, Callegaro D, Fujihara K, Aoki M.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 1 Issue: 11 Pages: 1257-1259
  • DOI: 10.1136/jnnp-2015-312676
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications (2016)
  • Author(s): Passos GR, Sato DK, Becker J, Fujihara K
  • Journal Title: Mediators Inflamm Volume: 1 Pages: 5314541-5314541
  • DOI: 10.1155/2016/5314541
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Age and gender effects on neuromyelitis optics spectrum disorder phenotypes (2015)
  • Author(s): Sato DK, Zago Melo P, Oliveira LM, Jorge FMH, Simm RF, Linhares G, Apostolos-Pereira SL, Fujihara K, Callegaro D.
  • Organizer: ECTRIMS - European Committee for the Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Clinically suspected neuromyelitis optics associated to anti-MOG antibodies. (2015)
  • Author(s): Paula Salles LMO, Sato DK, Apostolos-Pereira SL, Simm RF, Jorge FMH, Fujihara K, Callegaro D.
  • Organizer: ECTRIMS - European Committee for the Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Clinical phenotypes of paediatric and adult patients with anti-MOG antibodies. (2015)
  • Author(s): Sato DK, Kaneko K, Nakashima I, Tanaka S, Fukuyo N, Oliveira LM, Pandit L, Siritho S, Waters PJ, Takahashi T, Kuroda H, Nishiyama S, Akaishi T, Kurosawa K, Misu T, Prayoonwiwat N, Nomura K, Callegaro D, Fujihara K, Aoki M.
  • Organizer: ECTRIMS - European Committee for the Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Astrocyte and myelin injury in neuroinflammatory disorders with myelin oligodendrocyte glycoprotein or aquaporin-4 antibody positive cerebrospinal fluid. (2015)
  • Author(s): Kaneko K, Sato DK, Nakashima I, Nishiyama S, Tanaka S, Marignier R, Hyun JW, Kim HJ, Oliveira LM, Callegaro D, Reindl M, Berger T, Seifert-Held T, Saiz A, Sepulveda M, Siritho S, Prayoonwiwat N, Waters PJ, Kurosawa K, Akaishi T, Kuroda H, Misu T, Nomura K, Fujihara K, Aoki M.
  • Organizer: ECTRIMS - European Committee for the Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Antibodies to MOG and AQP4 in a patient with fulminant demyelinating encephalomyelitis, clinical course and neuropathological examination: a case report. (2015)
  • Author(s): Di Pauli F, Hoftberger R, Reindl M, Schanda K, Beer R, Sato DK, Fujihara K, Lassmann H, Schmutzhard E, Berger T.
  • Organizer: ECTRIMS - European Committee for the Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-07
  • Int'l Joint Research