Research Project
Grant-in-Aid for Young Scientists (B)
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder of peripheral nervous system. Current hypothesis is that humoral immune factors contribute to the autoimmune mechanisms. The aim of this study was to identify the immunological target antigens in subgroups of CIDP by proteomic-based approach. Target molecules of autoantibodies in the patient’s sera were investigated among extracted proteins from pig cauda equine by agarose 2-DE and immunoblotting. The candidate molecules were validated by immunoblotting, immunohistochemistry and immunocytochemistry.We found that some patients with CIDP had anti-vinculin autoantibodies. Vinculin exists ubiquitously and plays a key role in the cell adhesion.Our results suggested that vinculin could be a possible immunological target of autoantibodies in a few patients with typical CIDP.
All 2016 2015
All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)
J Neuroimmunol.
Volume: 287 Pages: 9-15
10.1016/j.jneuroim.2015.07.012
