Transcranial magnetic stimulation for treatment of neurological disorders
| Project/Area Number |
15K19476
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hamada Masashi 東京大学, 医学部附属病院, 助教 (40708054)
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| Research Collaborator |
SASAKI Takuya
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 経頭蓋磁気刺激法 / パーキンソン病 / 可塑性 / 経頭蓋磁気刺激 |
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| Outline of Final Research Achievements |
The aim of this project is to assess gait objectively, to identify the reason for variability of the effects of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and in patients with Parkinson's disease and to find more robust methods to induce plasticity in these subjects. First, we establish gait analysis system even in quadrepedal gait condition. Second, there are several factors to explain variability of rTMS such as age or baseline variability of cortical excitability. Third, although we had tried several method to induce more robust plasticity, such as changing brain state or stimulating multiple regions, we cannot find better way to induce consistent effects. Finally, we found that tuning the stimulation intensity may be a better way to induce consistent effects of rTMS.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] The intensity of continuous theta burst stimulation, but not the waveform used to elicit motor evoked potentials, influences its outcome in the human motor cortex.2018
Author(s)
Sasaki T, Kodama S, Togashi N, Shirota Y, Sugiyama Y, Tokushikge S, Inomata-Terada S, Terao Y, Ugawa Y, Hamada M
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Journal Title
Brain stimulation
Volume: 11
Issue: 2
Pages: 400-410
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasticity induced by non-invasive transcranial brain stimulation: a position paper.2017
Author(s)
Huang Y, Lu M, Antal A, Classen J, Nitsche M, Ziemann U, Ridding M, Hamada M, Ugawa Y, Jaberzadeh S, Suppa A, Paulus W, Rothwell J
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Journal Title
Clinical Neurophysiology
Volume: 128
Issue: 11
Pages: 2318-2329
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The effect of age on the homotopic motor cortical long-term potentiation-like effect induced by quadripulse stimulation2017
Author(s)
Hanajima R, Tanaka N, Tsutsumi R, Enomoto H, Abe M, Nakamura K, Kobayashi S, Hamada M, Shimizu T, Terao Y, Ugawa Y
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Journal Title
Exp Brain Res
Volume: 印刷中
Issue: 7
Pages: 2103-2108
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Variability in response to quadripulse stimulation of the motor cortex2016
Author(s)
Nakamura K, Groiss SJ, Hamada M, Enomoto H, Kadowaki S, Abe M, Murakami T, Wiratman W, Chang F, Kobayashi S, Hanajima R, Terao Y, Ugawa Y
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Journal Title
Brain Stimulation
Volume: 未
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Cerebellar Transcranial Direct Current Stimulation (ctDCS): A Novel Approach to Understanding Cerebellar Function in Health and Disease.2016
Author(s)
Grimaldi G, Argyropoulos GP, Bastian A, Cortes M, Davis NJ, Edwards DJ, Ferrucci R, Fregni F, Galea JM, Hamada M, Manto M, Miall RC, Morales-Quezada L, Pope PA, Priori A, Rothwell J, Tomlinson SP, Celnik P.
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Journal Title
Neuroscientist
Volume: 22(1)
Issue: 1
Pages: 83-97
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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