Tau deposition and microglial activation, amyroid deposition Alzheimer disease

• Project/Area Number: 15K19481
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
• Principal Investigator: Terada Tatsuhiro 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), 神経内科, その他 (80550178)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アルツハイマー病 / タウ / ミクログリア / アミロイド / PET / PBB3

Outline of Final Research Achievements

Amyloid-beta and tau are representative proteins that characterize the pathology of Alzheimer’s disease (AD). It remains unclear whether tau pathology and neuroinflammation occur in parallel. Tau and activated microglia can be depicted in vivo with a newly developed positron emission tomography (PET) tracers [11C]PBB3 and [11C]DPA713, respectively.AD patient at the CDR0.5 exhibited [11C]PBB3 BPND increase in the temporal and frontal cortex. In contrast, AD patient at the CDR1 showed greater elevation of [11C]PBB3 BPND more broadly in the temporal, parietal, and frontal cortices. In the right hippocampus, positive correlation was found between [11C]PBB3 BPND and [11C]DPA713 BPND.In addition, thre were significant correlation between increased [11C]PBB3 in the temporal area and amyroid deposition in the frontal area. Our results were consistent with tau spreading known in the AD pathology, and tau deposition may accompany microglial activation in the cerebral cortex.

Research Products

• [Journal Article] Correlation of frontal atrophy with behavioral changes in amyotrophic lateral sclerosis (2016)
  • Author(s): Tatsuhiro Terada, Tomokazu Obi, Jun Miyata, Manabu Kubota, Miho Yoshizumi, Toshiya Murai, Kinya Yamazaki and Kouichi Mizoguchi
  • Journal Title: Neurology and Clinical Neuroscience Volume: 4(3) Issue: 3 Pages: 85-92
  • DOI: 10.1111/ncn3.12046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study (2016)
  • Author(s): Tatsuhiro Terada, Masamichi Yokokura, Etsuji Yoshikawa, Masami Futatsubashi, Satoshi Kono, Takashi Konishi, Hiroaki Miyajima, Takanori Hashizume, Yasuomi Ouchi
  • Journal Title: Ann Nucl Med Volume: 30(8) Issue: 8 Pages: 579-87
  • DOI: 10.1007/s12149-016-1099-2
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Tau deposition and microglial activation in early stage Alzheimer disease (2016)
  • Author(s): Tatsuhiro Terada, Masamichi Yokokura, Tomoyasu Bunai, Etsuji Yoshikawa, Masami Futatsubashi, Yoshio Omote, Matsudaira Takashi, Yasukiyo Araki, Akira Sugiura, Tomokazu Obi, Yasuomi Ouchi
  • Organizer: Neuroscience2016
  • Place of Presentation: San Diego
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Tau deposition and microglial activation in early stage Alzheimer disease (2016)
  • Author(s): tatsuhiro terada
  • Organizer: society for neuroscience 2016
  • Place of Presentation: san diego
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Tau deposition and cognitive decline in early stage Alzheimer disease (2016)
  • Author(s): Tatsuhiro Terada, Tomoyasu Bunai, Etsuji Yoshikawa, Masami Futatsubashi, Yoshio Omote, Matsudaira Takashi, Yasukiyo Araki, Akira Sugiura, Tomokazu Obi, Yasuomi Ouchi
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
• [Presentation] 早期アルツハイマー病におけるタウ病変と認知機能低下 (2016)
  • Author(s): 寺田達弘
  • Organizer: 第39回日本神経科学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20