| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Patients with multiple system atrophy (MSA) show cognitive decline during the course of the illness. However an early diagnostic marker of cognitive decline of MSA remains unclear.We enrolled 30 cases with probable MSA and 15 healthy controls. We classified 15 patients who showed as normal cognition (MSA-NC) and 15 cases who showed as cognitive decline (MSA-CD). All subjects were investigated using brain volume/network analysis.
Results: Patients with MSA-NC and those with MSA-CD showed cerebellar but not cerebral atrophy compared to controls. In contrast, brain network analysis showed widespread abonormal values in both the cerebrum and cerebellum in MSA-CD compared to controls. Particularly, significant decreased fractional anisotrophy (FA) values were observed in the left corpus callosum in MSA-CD as compared to MSA-NC. It were significantly correlated with cognitive butteries. Decreased FA values in the corpus callosum could serve as an early indicator of cognitive decline in MSA.
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