Development of an early indicator in multiple system atrophy: brain network analysis

• Project/Area Number: 15K19484
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: HARA Kazuhiro 名古屋大学, 医学部附属病院, 医員 (80748369)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 多系統萎縮症 / 認知機能 / 脳内回路解析 / 脳梁 / 神経回路解析 / 画像解析 / 白質回路

Outline of Final Research Achievements

Patients with multiple system atrophy (MSA) show cognitive decline during the course of the illness. However an early diagnostic marker of cognitive decline of MSA remains unclear.We enrolled 30 cases with probable MSA and 15 healthy controls. We classified 15 patients who showed as normal cognition (MSA-NC) and 15 cases who showed as cognitive decline (MSA-CD). All subjects were investigated using brain volume/network analysis.
Results: Patients with MSA-NC and those with MSA-CD showed cerebellar but not cerebral atrophy compared to controls. In contrast, brain network analysis showed widespread abonormal values in both the cerebrum and cerebellum in MSA-CD compared to controls. Particularly, significant decreased fractional anisotrophy (FA) values were observed in the left corpus callosum in MSA-CD as compared to MSA-NC. It were significantly correlated with cognitive butteries. Decreased FA values in the corpus callosum could serve as an early indicator of cognitive decline in MSA.

Research Products

• [Journal Article] Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging (2016)
  • Author(s): Joe Senda, Hirohisa Watanabe, Kuniyuki Endo, Keizo Yasui, Yasuhiro Hawsegawa, Noritaka Yoneyama, Takashi Tsuboi, Kazuhiro Hara, Mizuki Ito, Naoki Atsuta, Bagarinao Epifanio Jr, Masahisa Katsuno, Shinji Naganawa, Gen Sobue
  • Journal Title: Nagoya Journal of Medical Science Volume: 78 Issue: 4 Pages: 455-463
  • DOI: 10.18999/nagjms.78.4.455
  • NAID: 120005889982
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/22946
  • Peer Reviewed / Open Access
• [Journal Article] Expanding concept of clinical conditions and symptoms in multiple system atrophy (2016)
  • Author(s): Watanabe H, Riku Y, Nakamura T, Hara K, Ito M, Hirayama M, Yoshida M, Katsuno M, Sobue G.
  • Journal Title: Rinsho Shinkeigaku Volume: 56 Issue: 7 Pages: 457-464
  • DOI: 10.5692/clinicalneurol.cn-000903
  • NAID: 130006882268
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed / Open Access
• [Journal Article] 拡散強調画像を用いた多系統萎縮症の上小脳脚病変の検討 (2015)
  • Author(s): 原 一洋
  • Journal Title: 神経内科 Volume: 82（6） Pages: 562-566
• [Presentation] 認知機能低下を示す多系統萎縮症の脳内ネットワ－ク解析所見 (2016)
  • Author(s): 原 一洋
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場(兵庫県 神戸市)
  • Year and Date: 2016-05-18
• [Presentation] 多系統萎縮症の脳内神経回路解析 (2015)
  • Author(s): 原 一洋
  • Organizer: 第33回日本神経治療学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-11-26