The development of novel biomarkers for amyotrophic lateral sclerosis using structural and functional neuroimaging
| Project/Area Number |
15K19487
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKO Wataru 徳島大学, 病院, 特任助教 (60581155)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 筋萎縮性側索硬化症 / バイオマーカー / MRI / fMRI / DTI / 機能的MRI / fractional anisotropy |
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| Outline of Final Research Achievements |
The development of objective biomarkers for amyotropic lateral sclerosis (ALS) is essential for accurate clinical trials. We hypothesized that structural and functional neuroimagings could be novel biomarkers for ALS. A reduced value of amplitude of low frequency fluctuation was found in the sensorimotor cortex in ALS using resting state functional magnetic resonance imaging (MRI). Fractional anisotropy in the supplementary motor area was reported to correlate with both disease duration and severity using structural MRI. Furthermore, MR spectroscopy revealed a correlation between N-acetyl aspartate/glutamate ratio and disease duration. These findings suggested that structural and functional neuroimagings might be helpful for recruitment and/or assessment of drug efficacy in clinical trials.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes2017
Author(s)
Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikane
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Journal Title
Nuclear Medicine Communications
Volume: 印刷中
Issue: 6
Pages: 487-492
DOI
Related Report
Peer Reviewed
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[Journal Article] MR Spectroscopy in Patients with Hereditary Diffuse Leukoencephalopathy with Spheroids and Asymptomatic Carriers of Colony-stimulating Factor 1 Receptor Mutation2017
Author(s)
Takashi Abe, Toshitaka Kawarai, Koji Fujita, Wataru Sako, Yuka Terasawa, Tsuyoshi Matsuda, Waka Sakai, Ai Tsukamoto-Miyashiro, Naoko Matsui, Yuishin Izumi, Ryuji Kaji, Masafumi Harada
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 16
Issue: 4
Pages: 297-303
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed
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[Journal Article] Clinical Significance of Discrepancy between Arterial Spin Labeling Images and Contrast-enhanced Images in the Diagnosis of Brain Tumors2015
Author(s)
Takashi Abe, Yoshifumi Mizobuchi, Wataru Sako, Saho Irahara, Yoichi Otomi, Yuki Obama, Kohei Nakajima, Delgerdalai Khashbat, Mungunkhuyag Majigsuren, Teruyoshi Kageji, Shinji Nagahiro, Masafumi Harada
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 14
Issue: 4
Pages: 313-319
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed
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