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Investigating the pathophysiology of impairment of large-scale brain networks in the patients with epilepsy

Research Project

Project/Area Number 15K19491
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionKyushu University

Principal Investigator

Uehara Taira  九州大学, 医学研究院, 助教 (30631585)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsてんかん / 機能的結合性 / 大域ネットワーク / デフォルトモードネットワーク / MRスぺクロスコピー
Outline of Final Research Achievements

We found rapid propagation of ictal fast activities including high-frequency oscillation (HFO) along well-known large-scale functional brain networks, such as default mode network (DMN), in the patients with intractable focal epilepsy. Interictal functional connectivity among DMN structures was not associated with the occurrence of ictal HFOs in DMN regions. The relation between hyperexcitability and functional connectivity of DMN in the patient with epilepsy was not clarified in this study.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer’s disease patients2018

    • Author(s)
      Yamashita Ken-ichiro、Uehara Taira、Prawiroharjo Pukovisa、Yamashita Koji、Togao Osamu、Hiwatashi Akio、Taniwaki Yoshihide、Utsunomiya Hidetsuna、Matsushita Takuya、Yamasaki Ryo、Kira Jun-ichi
    • Journal Title

      Brain Imaging and Behavior

      Volume: 印刷中 Issue: 1 Pages: 154-161

    • DOI

      10.1007/s11682-018-9860-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slowed abduction during smooth pursuit eye movement in episodic ataxia type 2 with a novel CACNA1A mutation2017

    • Author(s)
      Shimmura Mitsunori、Uehara Taira、Yamashita Kenichiro、Shigeto Hiroshi、Yamasaki Ryo、Ishikawa Kinya、Kira Jun-ichi
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 381 Pages: 4-6

    • DOI

      10.1016/j.jns.2017.07.040

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] てんかんの分類2017

    • Author(s)
      上原 平
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 35 Pages: 792-796

    • Related Report
      2017 Annual Research Report
  • [Presentation] 大規模機能的ネットワーク解析によるてんかんの病態解明2017

    • Author(s)
      上原 平
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭蓋内脳波による安静時ネットワークの解析とてんかん病態解明への応用2017

    • Author(s)
      上原 平
    • Organizer
      第5回アルツハイマー病とてんかんを考える会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Electrocorticographic analysis of spontaneous brain activity in patients with epilepsy2017

    • Author(s)
      Taira Uehara
    • Organizer
      神経オシレーションカンファレンス 2017「意識とネットワーク病」
    • Related Report
      2017 Annual Research Report
  • [Presentation] Interindividual variability in the occurrence of sleep spindles induced by interictal epileptiform discharges: an electrocorticographic analysis2017

    • Author(s)
      Taira Uehara, Takahiko Mukaino, Katsuya Ogata, Ayumi Sakata, Nobutaka Mukae, Kimiaki Hashiguchi, Jun-ichi Kira, Shozo Tobimatsu
    • Organizer
      World Congress of Neurology (WCN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional connectivity changes related to cognitive improvement by acetylcholine esterase inhibitors in Alzheimer disease2017

    • Author(s)
      Kenichiro Yamashita, Taira Uehara, Yoshihide Tanwaki, Hidetsuna Utsunomiya, Ryo Yamasaki, Jun-ichi Kira
    • Organizer
      World Congress of Neurology (WCN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRI陰性てんかんの診断におけるMRI postprocessingの有用性の検証2016

    • Author(s)
      上原 平, 茶谷 裕, 進村 光規, 重藤 寛史, 村井 弘之, 吉良 潤一
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report
  • [Presentation] 長時間ビデオ脳波モニターにおける抗てんかん薬の漸減・中止状況と発作出現時期の検討2016

    • Author(s)
      進村 光規, 茶谷 裕, 上原 平, 重藤 寛史, 酒田 あゆみ, 板倉 朋子, 渡邉 恵利子, 緒方 勝也, 橋口 公章, 迎 伸孝, 森岡 隆人, 飛松 省三, 吉良 潤一
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report
  • [Presentation] MRI 陰性と判断されたてんかん患者に潜在する皮質下帯状異所性灰白質の検討2016

    • Author(s)
      上原 平, 進村 光規, 向野 隆彦, 橋口 公章, 重藤 寛史, 吉良 潤一
    • Organizer
      第50回日本てんかん学会学術集会
    • Place of Presentation
      静岡
    • Related Report
      2016 Research-status Report
  • [Presentation] 長時間ビデオ脳波モニターにおける抗てんかん薬の漸減・中止状況の影響2016

    • Author(s)
      進村 光規, 向野 隆彦, 上原 平, 重藤 寛史, 酒田 あゆみ, 板倉 朋子, 渡邉 恵利子, 吉良 潤一
    • Organizer
      第50回日本てんかん学会学術集会
    • Place of Presentation
      静岡
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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