Investigating the pathophysiology of impairment of large-scale brain networks in the patients with epilepsy
| Project/Area Number |
15K19491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
Uehara Taira 九州大学, 医学研究院, 助教 (30631585)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | てんかん / 機能的結合性 / 大域ネットワーク / デフォルトモードネットワーク / MRスぺクロスコピー |
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| Outline of Final Research Achievements |
We found rapid propagation of ictal fast activities including high-frequency oscillation (HFO) along well-known large-scale functional brain networks, such as default mode network (DMN), in the patients with intractable focal epilepsy. Interictal functional connectivity among DMN structures was not associated with the occurrence of ictal HFOs in DMN regions. The relation between hyperexcitability and functional connectivity of DMN in the patient with epilepsy was not clarified in this study.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 長時間ビデオ脳波モニターにおける抗てんかん薬の漸減・中止状況と発作出現時期の検討2016
Author(s)
進村 光規, 茶谷 裕, 上原 平, 重藤 寛史, 酒田 あゆみ, 板倉 朋子, 渡邉 恵利子, 緒方 勝也, 橋口 公章, 迎 伸孝, 森岡 隆人, 飛松 省三, 吉良 潤一
Organizer
第57回日本神経学会学術大会
Place of Presentation
神戸
Related Report
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