Necessary environment for amelioration after ischemic reperfusion injury in brain: the role of L-serine
| Project/Area Number |
15K19497
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
Suzuki Masataka 慶應義塾大学, 医学部(信濃町), 特任助教 (90595000)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 虚血再灌流障害 / L-セリン / PHGDH / 脳虚血再灌流障害 / D-セリン / 脳虚血再韓流障害 / アストロサイト |
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| Outline of Final Research Achievements |
In this study, I aimed to clarify how L-serine , which is suplied by astroglia, affects on neurogenesis after ischemic reperfusion injury in brain of MCAO mouse model. The size of infarct region after MCAO in Astroglia specific knock out of phosphoglycerate dehydrogenase (PHGDH) was not significantly different from that in flox/flox mice. L-serine activated phosphorylation of p70S6K in primary cortical neurons in vitro. Because p70S6K is the protein that facilitates protein synthesis and cell proliferation, L-serine possibly stimulates neurogenesis.
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Report
(3 results)
Research Products
(1 results)
