| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Brain specific insulin receptor substrate (Irs)-1 knockout mice (NIrs1KO mice) showed lower body weight, smaller body length, shorter bone length and lower bone mineral density than control mice. Additionally serum levels of insulin-like growth factor (IGF)-1 and growth hormone (GH) were low, suggesting that NIrs1KO mice displayed growth retardation. We also found that hypothalamic growth hormone releasing hormone (GHRH) RNA expression was decreased in NIrs1KO mice and knockdown of Irs1 reduced IGF-1 mediated cell proliferation in hypothalamic neuronal cell line.
These results strongly indicate that Irs1 in the CNS plays an important role in growth by regulating neural proliferation.
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