| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We first investigated the incidence of diabetes after pancreatectomy (pancreatoduodenectomy; PD, distal pancreatectomy; DP). 4% and 48% of PD and DP developed diabetes 2 years after the surgery. Insulin secretion was decreased in DP but not in PD. GLP1 (hormone secreted from enteroendocrine L cells that can stimulate insulin secretion from beta cells) was robustly increased after PD. Patients with impaired glucose tolerance showed higher levels of histological markers for dedifferentiation of beta cells than those with normal glucose tolerance. Gut microbiota dramatically changed after PD. When stools obtained from the patients before and after PD were separately transplanted to germ-free mice, a significant difference was observed in glycemic control between the two group.
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