Therapeutic possibility of autophagy-lysosome pathway in diabetic nephropathy
| Project/Area Number |
15K19511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Yasuda Mako 滋賀医科大学, 医学部, 客員助教 (70731941)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖尿病性腎症 / 糸球体上皮細胞 / リソソーム |
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| Outline of Final Research Achievements |
Diabetic nephropathy is the leading cause of end stage renal disease. Thus, a new therapeutic strategy to combat the disease is strongly needed. Podocyte damage causes massive proteinuria, leading to rapid decline of renal function. However, the underlying mechanism of the situation is still unknown. It is presumed that the function of an intracellular catabolic mechanism, autophagy-lysosome system, is important for maintaining the survival and function of podocytes because they have poor regeneration capability. In this study, we have revealed that the autophagy-lysosomal system is impaired in podocytes of rats with severe diabetic nephropathy and the activation of lysosomal biosynthesis can reduce apoptosis in the cultured immortalized podocytes stimulated with glucose and lipid toxicity. The activation of autophagy-lysosomal system in podocytes may become a new therapeutic target for diabetic nephropathy.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017
Author(s)
Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
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Journal Title
Nephrol Dial Transplant.
Volume: 未定
Issue: 9
Pages: 000-000
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy.2016
Author(s)
Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T
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Journal Title
Diabetes.
Volume: -
Issue: 3
Pages: 755-767
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure.2015
Author(s)
Yasuda-Yamahara M, Kume S, Yamahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Ugi S, Maegawa H, Uzu T.
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Journal Title
Biochem Biophys Res Commun.
Volume: 18
Issue: 2
Pages: 249-255
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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