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The role of a-ketoglutarate dehydrogenase on insulin secretion

Research Project

Project/Area Number 15K19512
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionKyoto University

Principal Investigator

Ogura Masahito  京都大学, 医学研究科, 特定助教 (00547812)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsαKGDHのインスリン分泌に及ぼす影響
Outline of Final Research Achievements

TCA cycle is important for insulin secretion from pancreatic β cells via ATP synthesis. a-ketoglutarate dehydrogenase is one of the enzyme in TCA cycle. Recently, there are some reports that indicate relationship between diabetes and dementia. It is also reported that the activity of a-ketoglutarate dehydrogenase is inhibited in the neuron in Alzheimer disease by oxidative stress.
We investigate the effect of a-ketoglutarate dehydrogenase on insulin secretion from pancreatic β cells using cell line or isolated islet from rodents. It was revealed that insulin secretion is affected by the inhibition of a-ketoglutarate dehydrogenase or depression of expression levels of a-ketoglutarate dehydrogenase.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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