Research Project
Grant-in-Aid for Young Scientists (B)
TCA cycle is important for insulin secretion from pancreatic β cells via ATP synthesis. a-ketoglutarate dehydrogenase is one of the enzyme in TCA cycle. Recently, there are some reports that indicate relationship between diabetes and dementia. It is also reported that the activity of a-ketoglutarate dehydrogenase is inhibited in the neuron in Alzheimer disease by oxidative stress.We investigate the effect of a-ketoglutarate dehydrogenase on insulin secretion from pancreatic β cells using cell line or isolated islet from rodents. It was revealed that insulin secretion is affected by the inhibition of a-ketoglutarate dehydrogenase or depression of expression levels of a-ketoglutarate dehydrogenase.
