| Project/Area Number |
15K19516
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Hiroshima University |
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Principal Investigator |
Asada Rie 広島大学, 医歯薬保健学研究院(医), 助教 (70751882)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小胞体ストレス応答 / 褐色脂肪細胞 / UCP1 / IRE1α / XBP1 |
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| Outline of Final Research Achievements |
The unfolded protein response (UPR) not only resolves endoplasmic reticulum (ER) stress, but also regulates cellular physiological functions such as proliferation, differentiation, and energy metabolism. In this study, we explored the physiological role of UPR in brown adipocytes. We found the one of UPR branch, IRE1alpha -XBP1 pathway, is crucial for the transcriptional induction of thermogenin UCP1. We also revealed that tissue-specific ER stress transducer BBF2H7 is involved in the differentiation of brown adipocytes.
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