| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
As for the pathophysiological significance of the macrophage proliferation in the atherosclerosis, there are still many questions left to be answered. To verify the direct evidence of involvement of local macrophage proliferation for atherosclerosis, we generated transgenic mice received p27kip expression only in the macrophages(mac-p27Tg), whose macrophage proliferation was specifically inhibited. The aortic valve annulus section average plaque area was significantly reduced in mac-p27Tg, compared with that of the control. The percentage of the necrotic core to the total advanced lesion area significantly decreased in mac-p27Tg. The inflammatory cytokines were also reduced in mac-p27Tg. We found that the local macrophage proliferation could be one of the common underlying pathophysiological features in the formation and the progression of atherosclerosis. Our results might lead to the control of the macrophage proliferation as the therapeutic target for atherosclerotic disease.
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