Research Project
Grant-in-Aid for Young Scientists (B)
It is well known that metabolic syndrome is associated with lifestyle and genetic factor but precise mechanism of pathogenesis of metabolic syndrome is unclear. Present study found that in metabolic syndrome-associated gene KAT1 knockout mice kynurenic acid contents in some tissues was decreased and glucose intolerance and insulin-resistant state were observed. Furthermore, increasing endogenous kynurenic acid contents ameliorated glucose intolerance in diabetic mice with diet-induced obesity. The therapeutic intervention to manipulate metabolism of kynurenic acid may be an effective tool for controlling progression of diabetes mellitus and metabolic syndrome.
All 2017
All Presentation (3 results)
