Exploration of the mechanisms for supplying octanoic acid for ghrelin acylation in X/A-like cells.
Project/Area Number |
15K19532
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | Wakayama Medical University |
Principal Investigator |
BANDO MIKA 和歌山県立医科大学, 医学部, 特別研究員 (70737874)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | グレリン / アシル化 / 長鎖脂肪酸 / 炎症 / IL-1 |
Outline of Final Research Achievements |
The mechanisms for supplying octanoic acid for ghrelin acylation in X/A-like cells are incompletely understood. We found that long-chain fatty acids were incorporated at a higher rate in the ghrelin-producing cell line MGN3-1 than in MIN6 cells, in part due to higher expression level of long-chain fatty acyl-CoA synthetase family member 1 (Acsl1). Inhibition of ACSLs by triacsin C profoundly suppressed acylated ghrelin production. These results suggest that high incorporation of long-chain fatty acids into the ghrelin-producing cells plays a role in the supply of octanoic acid for ghrelin acylation.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells.2016
Author(s)
Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, Kusakabe T, Son C, Hosoda K, Akamizu T, Kangawa K, Nakao K.
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Journal Title
Endocrinology
Volume: 157
Issue: 2
Pages: 692-704
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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